Double filtration plasmapheresis for a case of Crimean-Congo hemorrhagic fever

Abstract Crimean-Congo hemorrhagic fever (CCHF), is a fatal viral infection transmitted to humans through a tick bite or exposure to blood or tissues of viremic hosts. The clinical presentation is characterized by sudden onset high fever, headache, myalgia, abdominal pain and nausea–vomiting followe...

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Bibliographic Details
Published in:Transfusion and apheresis science 2013-06, Vol.48 (3), p.331-334
Main Authors: Meço, Başak C, Memikoğlu, Osman, İlhan, Osman, Ayyıldız, Erol, Gunt, Ceren, Ünal, Necmettin, Oral, Mehmet, Tulunay, Melek
Format: Article
Language:English
Subjects:
Adult
Animals
Fibrinogen - biosynthesis
Filtration
Health technology assessment
Hematology, Oncology and Palliative Medicine
Hemorrhagic Fever Virus, Crimean-Congo
Hemorrhagic Fever, Crimean - therapy
Humans
International Normalized Ratio
Ixodidae
Male
Plasmapheresis - methods
Ribavirin - therapeutic use
Tick Bites
Treatment Outcome
Viral Load
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Summary:Abstract Crimean-Congo hemorrhagic fever (CCHF), is a fatal viral infection transmitted to humans through a tick bite or exposure to blood or tissues of viremic hosts. The clinical presentation is characterized by sudden onset high fever, headache, myalgia, abdominal pain and nausea–vomiting followed by gastrointestinal, urinary, respiratory tract and brain hemorrhage. Laboratory findings include leucopenia, thrombocytopenia, elevated liver enzymes, prolonged prothrombin time and activated partial thromboplastin time. We report a case of CCHF who was treated with a combination of DFPP and ribavirin therapy. As a result of this multimodal treatment, patient’s clinical symptoms and laboratory findings improved gradually.
ISSN:1473-0502
1878-1683
DOI:10.1016/j.transci.2013.04.011