New luminescent probe based on a terbium(III) complex for studying DNA affinity of aminoalkoxy fluorenones

We have studied the spectral luminescent properties of complexes of Tb(III) ions with a series of new derivatives of 2-oxo-4-hydroxyquinoline-3-carboxylic acid amides (L 1 –L 4 ). We have established that DNA significantly enhances the 4f luminescence of terbium(III) in these complex compounds. We s...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2013-07, Vol.80 (3), p.429-436
Main Authors: Yegorova, А. V., Leonenko, I. I., Scrypynets, Yu. V., Antonovich, V. P., Malzev, G. V., Ukrainets, I. V., Aleksandrova, D. I.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Atomic/Molecular Structure and Spectra
DNA
Genetic research
Investigations
Physics
Physics and Astronomy
Rare earth metals
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Summary:We have studied the spectral luminescent properties of complexes of Tb(III) ions with a series of new derivatives of 2-oxo-4-hydroxyquinoline-3-carboxylic acid amides (L 1 –L 4 ). We have established that DNA significantly enhances the 4f luminescence of terbium(III) in these complex compounds. We show satisfactory agreement between the logarithms of the DNA binding constants for a series of aminoalkoxy fluorenones (R 1 –R 6 ), obtained using ethidium bromide and the complex Tb(III)-L 1 , which we propose using as a new luminescent probe for studying the affinity of drugs (prodrugs) for DNA molecules in a series of structurally similar biologically active substances.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-013-9784-6