Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma

Summary Background The diagnosis of phaeochromocytoma is commonly performed by the measurements of plasma‐free normetanephrine and metanephrine. Plasma‐deconjugated normetanephrine and metanephrine have been proposed as alternative, equivalent, but easier to measure biomarkers. Objective The aim of...

Full description

Saved in:
Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2013-10, Vol.79 (4), p.476-483
Main Authors: Pamporaki, Christina, Därr, Roland, Bursztyn, Michael, Glöckner, Stephan, Bornstein, Stefan R., Lenders, Jacques W. M., Pacak, Karel, Krinner, Axel, Eisenhofer, Graeme
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - blood
Adrenal Gland Neoplasms - complications
Adrenal Gland Neoplasms - diagnosis
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adult
Biological and medical sciences
Biomarkers, Tumor - blood
Chromatography, Liquid
Electrochemical Techniques
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypertension - blood
Hypertension - complications
Male
Medical sciences
Metanephrine - blood
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Normetanephrine - blood
Pheochromocytoma - blood
Pheochromocytoma - complications
Pheochromocytoma - diagnosis
ROC Curve
Vertebrates: endocrinology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background The diagnosis of phaeochromocytoma is commonly performed by the measurements of plasma‐free normetanephrine and metanephrine. Plasma‐deconjugated normetanephrine and metanephrine have been proposed as alternative, equivalent, but easier to measure biomarkers. Objective The aim of this study was to compare the diagnostic performance of plasma‐free vs deconjugated normetanephrine and metanephrine in patients tested for phaeochromocytoma. Methods The study population included a reference group of 262 normotensive and hypertensive volunteers, 198 patients with phaeochromocytoma and 528 patients initially suspected of having the tumour, but with negative investigations after at least 2 years of follow‐up. Measurements were performed using liquid chromatography with electrochemical detection. Results Plasma concentrations of free normetanephrine were 17‐fold higher in patients with phaeochromocytoma than in the reference population, a 72% larger (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12191