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Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults
Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged
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| Published in: | European archives of oto-rhino-laryngology 2013, Vol.270 (1), p.271-276 |
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| creator | Kostrzewska-Poczekaj, M. Gawęcki, W. Illmer, J. Rydzanicz, M. Gajecka, M. Szyfter, W. Szyfter, K. |
| description | Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged |
| doi_str_mv | 10.1007/s00405-012-1993-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1430861242</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1430861242</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-409d4b7b3e199f552d5f8f55e11371234d521e9c27605b02beeaf0aa985d92803</originalsourceid><addsrcrecordid>eNqFkb1T4zAQxTUMDITc_QE0jEoac6sPW1bJ8HkzzEHB1RrZXidObClIcZH_HvkSKLlqi_fbN7vvEXLB4JoBqF8RQEKeAeMZ01pk5RGZMSlkJhUvjskMtFCZlEqdkfMYVwCQSy1OyRnnkisQMCOrV9_vBh82yy4OkfqW3v25oQE3tgt0gQ4jta6hoYvrSYzvox38GGmNfU9rG-rO-cFO0naJdIm2-cc7rNe0c3TnR7egthn7bfxBTlrbR_x5mHPy9-H-7fYpe355_H1785zVQqltJkE3slKVwPRTm-e8ydsyTWRMKMaFbHLOUNdcFZBXwCtE24K1uswbzUsQc3K1990E_z5i3Jqhi9O91mE63aSEoCxYiuD_KFeCFUrpIqFsj9bBxxiwNZvQDTbsDAMztWH2bZjUhpnaMGXauTzYj9WAzdfGZ_wJ4HsgJsktMJiVH4NL6Xzj-gEKvZO6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1273167796</pqid></control><display><type>article</type><title>Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults</title><source>Springer Link</source><creator>Kostrzewska-Poczekaj, M. ; Gawęcki, W. ; Illmer, J. ; Rydzanicz, M. ; Gajecka, M. ; Szyfter, W. ; Szyfter, K.</creator><creatorcontrib>Kostrzewska-Poczekaj, M. ; Gawęcki, W. ; Illmer, J. ; Rydzanicz, M. ; Gajecka, M. ; Szyfter, W. ; Szyfter, K.</creatorcontrib><description>Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged <45 years are categorized as young adults (YA). They are characterized by more severe form of this disease and often lack of classical, causative risk factors (tobacco smoking, alcohol abusing) in comparison to older (typical) patients (OP). The study purpose was to establish an anticipated protective role of DNA repair genes polymorphisms against cancer-causing agents. It was assumed that the polymorphisms in these genes may have a significant role in the etiology of HNSCC in YA. Studies were carried out on three groups: YA group with HNSCC (
n
= 90), young healthy group without cancer (YH,
n
= 160) and OP with HNSCC (
n
= 205). Three polymorphisms in DNA repair genes were analyzed:
XPD
ex23: A35931C,
XRCC1
ex10: G28152A, and
XRCC3
ex7: C18067T. The choice of these genes was connected with their involvement in three different DNA repair pathways. Genotyping was carried out by polymerase chain reaction with restriction fragment length polymorphism (PCR–RFLP) technique. Statistical analysis included: calculation of odds ratio (ORs), 95 % confidence intervals (CIs) and
p
value. There was no significant difference in the distribution of
XPD
genotypes in YA compared to OP or YH. The
XRCC1
AA genotype variant was observed less frequently in HNSCC YA (4.7 %) than in YH and in OP group (17.1 and 10.8 %, respectively).
XRCC3
CT genotype variant was observed more frequently in HNSCC YA (61.8 %) than in YH (36.3 %) and this result is statistically significant. This variant was associated with the borderline increased risk of HNSCC development in an early age, however, a similar tendency was not observed in case of double mutated TT variant. The established differences of genotypes distribution do not seem to differentiate substantially YA and OP in head and neck cancer risk.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-012-1993-8</identifier><identifier>PMID: 22427030</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alleles ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Chi-Square Distribution ; DNA Repair ; DNA-Binding Proteins - genetics ; Female ; Genotype ; Head and Neck ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - pathology ; Head and Neck Surgery ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Neurosurgery ; Otorhinolaryngology ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Risk Factors ; X-ray Repair Cross Complementing Protein 1 ; Xeroderma Pigmentosum Group D Protein - genetics</subject><ispartof>European archives of oto-rhino-laryngology, 2013, Vol.270 (1), p.271-276</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-409d4b7b3e199f552d5f8f55e11371234d521e9c27605b02beeaf0aa985d92803</citedby><cites>FETCH-LOGICAL-c377t-409d4b7b3e199f552d5f8f55e11371234d521e9c27605b02beeaf0aa985d92803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22427030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kostrzewska-Poczekaj, M.</creatorcontrib><creatorcontrib>Gawęcki, W.</creatorcontrib><creatorcontrib>Illmer, J.</creatorcontrib><creatorcontrib>Rydzanicz, M.</creatorcontrib><creatorcontrib>Gajecka, M.</creatorcontrib><creatorcontrib>Szyfter, W.</creatorcontrib><creatorcontrib>Szyfter, K.</creatorcontrib><title>Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged <45 years are categorized as young adults (YA). They are characterized by more severe form of this disease and often lack of classical, causative risk factors (tobacco smoking, alcohol abusing) in comparison to older (typical) patients (OP). The study purpose was to establish an anticipated protective role of DNA repair genes polymorphisms against cancer-causing agents. It was assumed that the polymorphisms in these genes may have a significant role in the etiology of HNSCC in YA. Studies were carried out on three groups: YA group with HNSCC (
n
= 90), young healthy group without cancer (YH,
n
= 160) and OP with HNSCC (
n
= 205). Three polymorphisms in DNA repair genes were analyzed:
XPD
ex23: A35931C,
XRCC1
ex10: G28152A, and
XRCC3
ex7: C18067T. The choice of these genes was connected with their involvement in three different DNA repair pathways. Genotyping was carried out by polymerase chain reaction with restriction fragment length polymorphism (PCR–RFLP) technique. Statistical analysis included: calculation of odds ratio (ORs), 95 % confidence intervals (CIs) and
p
value. There was no significant difference in the distribution of
XPD
genotypes in YA compared to OP or YH. The
XRCC1
AA genotype variant was observed less frequently in HNSCC YA (4.7 %) than in YH and in OP group (17.1 and 10.8 %, respectively).
XRCC3
CT genotype variant was observed more frequently in HNSCC YA (61.8 %) than in YH (36.3 %) and this result is statistically significant. This variant was associated with the borderline increased risk of HNSCC development in an early age, however, a similar tendency was not observed in case of double mutated TT variant. The established differences of genotypes distribution do not seem to differentiate substantially YA and OP in head and neck cancer risk.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Chi-Square Distribution</subject><subject>DNA Repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Head and Neck</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Risk Factors</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><subject>Xeroderma Pigmentosum Group D Protein - genetics</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkb1T4zAQxTUMDITc_QE0jEoac6sPW1bJ8HkzzEHB1RrZXidObClIcZH_HvkSKLlqi_fbN7vvEXLB4JoBqF8RQEKeAeMZ01pk5RGZMSlkJhUvjskMtFCZlEqdkfMYVwCQSy1OyRnnkisQMCOrV9_vBh82yy4OkfqW3v25oQE3tgt0gQ4jta6hoYvrSYzvox38GGmNfU9rG-rO-cFO0naJdIm2-cc7rNe0c3TnR7egthn7bfxBTlrbR_x5mHPy9-H-7fYpe355_H1785zVQqltJkE3slKVwPRTm-e8ydsyTWRMKMaFbHLOUNdcFZBXwCtE24K1uswbzUsQc3K1990E_z5i3Jqhi9O91mE63aSEoCxYiuD_KFeCFUrpIqFsj9bBxxiwNZvQDTbsDAMztWH2bZjUhpnaMGXauTzYj9WAzdfGZ_wJ4HsgJsktMJiVH4NL6Xzj-gEKvZO6</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Kostrzewska-Poczekaj, M.</creator><creator>Gawęcki, W.</creator><creator>Illmer, J.</creator><creator>Rydzanicz, M.</creator><creator>Gajecka, M.</creator><creator>Szyfter, W.</creator><creator>Szyfter, K.</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>2013</creationdate><title>Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults</title><author>Kostrzewska-Poczekaj, M. ; Gawęcki, W. ; Illmer, J. ; Rydzanicz, M. ; Gajecka, M. ; Szyfter, W. ; Szyfter, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-409d4b7b3e199f552d5f8f55e11371234d521e9c27605b02beeaf0aa985d92803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Chi-Square Distribution</topic><topic>DNA Repair</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Head and Neck</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Risk Factors</topic><topic>X-ray Repair Cross Complementing Protein 1</topic><topic>Xeroderma Pigmentosum Group D Protein - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kostrzewska-Poczekaj, M.</creatorcontrib><creatorcontrib>Gawęcki, W.</creatorcontrib><creatorcontrib>Illmer, J.</creatorcontrib><creatorcontrib>Rydzanicz, M.</creatorcontrib><creatorcontrib>Gajecka, M.</creatorcontrib><creatorcontrib>Szyfter, W.</creatorcontrib><creatorcontrib>Szyfter, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kostrzewska-Poczekaj, M.</au><au>Gawęcki, W.</au><au>Illmer, J.</au><au>Rydzanicz, M.</au><au>Gajecka, M.</au><au>Szyfter, W.</au><au>Szyfter, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2013</date><risdate>2013</risdate><volume>270</volume><issue>1</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Squamous cell carcinoma of the head and neck (HNSCC) most frequently arise in the epithelial tissues of the upper aerodigestive tract. Patients with HNSCC, aged <45 years are categorized as young adults (YA). They are characterized by more severe form of this disease and often lack of classical, causative risk factors (tobacco smoking, alcohol abusing) in comparison to older (typical) patients (OP). The study purpose was to establish an anticipated protective role of DNA repair genes polymorphisms against cancer-causing agents. It was assumed that the polymorphisms in these genes may have a significant role in the etiology of HNSCC in YA. Studies were carried out on three groups: YA group with HNSCC (
n
= 90), young healthy group without cancer (YH,
n
= 160) and OP with HNSCC (
n
= 205). Three polymorphisms in DNA repair genes were analyzed:
XPD
ex23: A35931C,
XRCC1
ex10: G28152A, and
XRCC3
ex7: C18067T. The choice of these genes was connected with their involvement in three different DNA repair pathways. Genotyping was carried out by polymerase chain reaction with restriction fragment length polymorphism (PCR–RFLP) technique. Statistical analysis included: calculation of odds ratio (ORs), 95 % confidence intervals (CIs) and
p
value. There was no significant difference in the distribution of
XPD
genotypes in YA compared to OP or YH. The
XRCC1
AA genotype variant was observed less frequently in HNSCC YA (4.7 %) than in YH and in OP group (17.1 and 10.8 %, respectively).
XRCC3
CT genotype variant was observed more frequently in HNSCC YA (61.8 %) than in YH (36.3 %) and this result is statistically significant. This variant was associated with the borderline increased risk of HNSCC development in an early age, however, a similar tendency was not observed in case of double mutated TT variant. The established differences of genotypes distribution do not seem to differentiate substantially YA and OP in head and neck cancer risk.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22427030</pmid><doi>10.1007/s00405-012-1993-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Alleles Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Chi-Square Distribution DNA Repair DNA-Binding Proteins - genetics Female Genotype Head and Neck Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Surgery Humans Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Neoplasm Staging Neurosurgery Otorhinolaryngology Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Risk Factors X-ray Repair Cross Complementing Protein 1 Xeroderma Pigmentosum Group D Protein - genetics |
| title | Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults |
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