Antibacterial Activity of Substituted 1,3-Dioxolanes

Cyclic ketals and acetals (1,3-dioxolanes) substituted at positions 2 and 4 of the dioxolane ring, prepared by condensation of glycerol and ethylene glycol with aldehydes and ketones, had antimicrobial activity against Gram-positive and Gram-negative bacteria. This activity, which may be associated...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2013-06, Vol.47 (3), p.142-145
Main Authors: Ovsyannikova, M. N., Vol’eva, V. B., Belostotskaya, I. S., Komissarova, N. L., Malkova, A. V., Kurkovskaya, L. N.
Format: Article
Language:English
Subjects:
Antibacterial agents
Ethylene glycol
Glycerin
Glycerol
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Cyclic ketals and acetals (1,3-dioxolanes) substituted at positions 2 and 4 of the dioxolane ring, prepared by condensation of glycerol and ethylene glycol with aldehydes and ketones, had antimicrobial activity against Gram-positive and Gram-negative bacteria. This activity, which may be associated with the antiradical activity of the study compounds and depended on their hydrophilic-hydrophobic balance, allows targeted variation in structural parameters for the creation of new active compounds. Cyclic ketals with high antimicrobial activity can be used as antiseptics for sterilization of working surfaces and instruments.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-013-0913-6