Plasma Lipoproteins as a Transport Form of Extracellular DNA

We showed DNA-binding activity of different classes of plasma lipoproteins in rats and humans. Experiments with fluorescent dye Hoechst 33258 showed that about 12% extracellular plasma DNA is present in circulating lipoproteins complexes; 7-8% of them with HDL. Structural HDL protein apoA-I probably...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.622-623
Main Authors: Sumenkova, D. V., Polyakov, L. M., Panin, L. E.
Format: Article
Language:English
Subjects:
Animals
Apolipoprotein A-I - blood
Apolipoprotein A-I - metabolism
Apolipoproteins
Biological Transport
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Blood lipids
Cell Biology
DNA
DNA - blood
DNA - metabolism
DNA-Binding Proteins - blood
DNA-Binding Proteins - metabolism
Humans
Internal Medicine
Laboratory Medicine
Lipoproteins, HDL - blood
Lipoproteins, HDL - metabolism
Male
Pathology
Rats
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Summary:We showed DNA-binding activity of different classes of plasma lipoproteins in rats and humans. Experiments with fluorescent dye Hoechst 33258 showed that about 12% extracellular plasma DNA is present in circulating lipoproteins complexes; 7-8% of them with HDL. Structural HDL protein apoA-I probably plays the major role in the interaction between extracellular DNA and lipoprotein particle. Participation of lipoproteins in the transport of extracellular DNA can be considered as an important mechanism for elimination of nucleic acids from blood plasma.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2014-7