Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats

The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.642-644
Main Authors: Kraineva, V. A., Gudasheva, T. A., Kotelnikova, S. O., Antipova, T. A., Seredenin, S. B.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dipeptides - therapeutic use
Disease Models, Animal
Glutamine
Internal Medicine
Intracranial Hemorrhages - drug therapy
Intracranial Hemorrhages - mortality
Laboratory Medicine
Male
Nerve Growth Factor
Neuroprotective Agents - therapeutic use
Pathology
Pharmacology and Toxicology
Rats
Stroke - drug therapy
Stroke - mortality
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Summary:The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in a dose of 1 mg/kg 4 and 24 h after surgery and 24 h before testing the CNS function on days 3, 7, and 14 prevent death of experimental animals, reduce the neurological deficit, and normalized behavior.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2020-9