Pericarditis mediated by respiratory syncytial virus in a hematopoietic stem cell transplant patient

We describe a case of pericarditis and large pericardial effusion in a 63‐year‐old African‐American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma. Pericardial tissue biopsy demonstrated fibrinous pericarditis, and immunohistochemistry stains were positive for resp...

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Bibliographic Details
Published in:Transplant infectious disease 2013-08, Vol.15 (4), p.E152-E156
Main Authors: Rubach, M.P., Pavlisko, E.N., Perfect, J.R.
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
hematopoietic stem cell transplant
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immunoglobulins, Intravenous - therapeutic use
IVIg
Male
Medical research
Middle Aged
multiple myeloma
Multiple Myeloma - therapy
Pericardial Effusion - drug therapy
pericarditis
Pericarditis - diagnosis
Pericarditis - drug therapy
Pericarditis - virology
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - drug therapy
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - isolation & purification
Ribavirin
Stem cells
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Summary:We describe a case of pericarditis and large pericardial effusion in a 63‐year‐old African‐American man undergoing autologous hematopoietic stem cell transplant for multiple myeloma. Pericardial tissue biopsy demonstrated fibrinous pericarditis, and immunohistochemistry stains were positive for respiratory syncytial virus. The patient improved with oral ribavirin and intravenous immune globulin infusions.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12099