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Statistic Parametric Mapping of Changes in Gene Activity in Animal Brain during Acoustic Stimulation
We analyzed the expression of transcription factor c-Fos induced by neural activity in the mouse brain after acoustic stimulation. The brain sections of the animals subjected to acoustic stimulation and controls were immunohistochemically stained for c-Fos protein. Statistical parametric mapping (SP...
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| Published in: | Bulletin of experimental biology and medicine 2013-03, Vol.154 (5), p.697-699 |
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| Main Authors: | , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c503t-a068b3305aab7e2b269f61c8ed90f979dcef9f7cf3431f27ac8d3d6d450e97923 |
| container_end_page | 699 |
| container_issue | 5 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Amelchenko, E. M. Osokin, A. A. Zworikina, S. V. Chekhov, S. A. Lebedev, A. E. Voronin, P. A. Galatenko, V. V. Vetrov, D. P. Anokhin, K. V. |
| description | We analyzed the expression of transcription factor c-Fos induced by neural activity in the mouse brain after acoustic stimulation. The brain sections of the animals subjected to acoustic stimulation and controls were immunohistochemically stained for c-Fos protein. Statistical parametric mapping (SPM) was used to identify group differences in the acquired images. c-Fos expression was significantly higher in the auditory cortex, amygdala, and hippocampus CA3 area after tone presentation. The proposed combination of SPM with molecularbiological approach to visualization of transcription in the nerve cells makes it possible to identify the collaborative activation of distant brain structures assumed to be the components of united functional systems. |
| doi_str_mv | 10.1007/s10517-013-2032-5 |
| format | article |
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M. ; Osokin, A. A. ; Zworikina, S. V. ; Chekhov, S. A. ; Lebedev, A. E. ; Voronin, P. A. ; Galatenko, V. V. ; Vetrov, D. P. ; Anokhin, K. V.</creator><creatorcontrib>Amelchenko, E. M. ; Osokin, A. A. ; Zworikina, S. V. ; Chekhov, S. A. ; Lebedev, A. E. ; Voronin, P. A. ; Galatenko, V. V. ; Vetrov, D. P. ; Anokhin, K. V.</creatorcontrib><description>We analyzed the expression of transcription factor c-Fos induced by neural activity in the mouse brain after acoustic stimulation. The brain sections of the animals subjected to acoustic stimulation and controls were immunohistochemically stained for c-Fos protein. Statistical parametric mapping (SPM) was used to identify group differences in the acquired images. c-Fos expression was significantly higher in the auditory cortex, amygdala, and hippocampus CA3 area after tone presentation. The proposed combination of SPM with molecularbiological approach to visualization of transcription in the nerve cells makes it possible to identify the collaborative activation of distant brain structures assumed to be the components of united functional systems.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-013-2032-5</identifier><identifier>PMID: 23658901</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acoustic Stimulation ; Amygdala ; Amygdala - metabolism ; Animals ; Auditory Cortex - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - metabolism ; Brain Mapping ; Cell Biology ; Gene Expression ; Genes ; Hippocampus - metabolism ; Internal Medicine ; Laboratory Medicine ; Male ; Methods ; Mice ; Mice, Inbred C57BL ; Neurons - metabolism ; Pathology ; Proto-Oncogene Proteins c-fos - genetics ; Proto-Oncogene Proteins c-fos - metabolism ; Statistics</subject><ispartof>Bulletin of experimental biology and medicine, 2013-03, Vol.154 (5), p.697-699</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a068b3305aab7e2b269f61c8ed90f979dcef9f7cf3431f27ac8d3d6d450e97923</citedby><cites>FETCH-LOGICAL-c503t-a068b3305aab7e2b269f61c8ed90f979dcef9f7cf3431f27ac8d3d6d450e97923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23658901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amelchenko, E. M.</creatorcontrib><creatorcontrib>Osokin, A. A.</creatorcontrib><creatorcontrib>Zworikina, S. V.</creatorcontrib><creatorcontrib>Chekhov, S. A.</creatorcontrib><creatorcontrib>Lebedev, A. E.</creatorcontrib><creatorcontrib>Voronin, P. A.</creatorcontrib><creatorcontrib>Galatenko, V. V.</creatorcontrib><creatorcontrib>Vetrov, D. P.</creatorcontrib><creatorcontrib>Anokhin, K. V.</creatorcontrib><title>Statistic Parametric Mapping of Changes in Gene Activity in Animal Brain during Acoustic Stimulation</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We analyzed the expression of transcription factor c-Fos induced by neural activity in the mouse brain after acoustic stimulation. The brain sections of the animals subjected to acoustic stimulation and controls were immunohistochemically stained for c-Fos protein. Statistical parametric mapping (SPM) was used to identify group differences in the acquired images. c-Fos expression was significantly higher in the auditory cortex, amygdala, and hippocampus CA3 area after tone presentation. The proposed combination of SPM with molecularbiological approach to visualization of transcription in the nerve cells makes it possible to identify the collaborative activation of distant brain structures assumed to be the components of united functional systems.</description><subject>Acoustic Stimulation</subject><subject>Amygdala</subject><subject>Amygdala - metabolism</subject><subject>Animals</subject><subject>Auditory Cortex - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain Mapping</subject><subject>Cell Biology</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Hippocampus - metabolism</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurons - metabolism</subject><subject>Pathology</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Statistics</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkl1vFCEUhonR2LX6A7wxk5gYb6YeOPPBXI4brSY1mlSvCcvALs0MMwJj0n8vuFVbozFc8PW8Lxx4CXlK4YwCtK8ChZq2JVAsGSAr63tkQ-sWS84YvU82kKCy4pyfkEchXOUpNPQhOWHY1LwDuiHDZZTRhmhV8Ul6Oeno0_CDXBbr9sVsiu1Bur0OhXXFuXa66FW032y8zgu9s5Mci9depsmw-izp1bz-sLuMdlrHZD67x-SBkWPQT276U_Ll7ZvP23flxcfz99v-olQ1YCwlNHyHCLWUu1azHWs601DF9dCB6dpuUNp0plUGK6SGtVLxAYdmqGrQaZvhKXl59F38_HXVIYrJBqXHUTqdbiVohcAbBNr9H8UaaNV1SBP6_A_0al69S4UkQ4oVMN5Wv6m9HLWwzszRS5VNRY_IATmDfOzZX6jUBj1ZNTttbFq_I3hxS3DQcoyHMI9rftZwF6RHUPk5BK-NWHz6HX8tKIicFnFMi0hpETktok6aZzeVrbtJD78UP-ORAHYEwpI_V_tbpf_T9TvI38Zs</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Amelchenko, E. 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M. ; Osokin, A. A. ; Zworikina, S. V. ; Chekhov, S. A. ; Lebedev, A. E. ; Voronin, P. A. ; Galatenko, V. V. ; Vetrov, D. P. ; Anokhin, K. 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| subjects | Acoustic Stimulation Amygdala Amygdala - metabolism Animals Auditory Cortex - metabolism Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Brain Mapping Cell Biology Gene Expression Genes Hippocampus - metabolism Internal Medicine Laboratory Medicine Male Methods Mice Mice, Inbred C57BL Neurons - metabolism Pathology Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Statistics |
| title | Statistic Parametric Mapping of Changes in Gene Activity in Animal Brain during Acoustic Stimulation |
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