Regression of Endometrial Implants by Resveratrol in an Experimentally Induced Endometriosis Model in Rats

Objective: To evaluate the effect of resveratrol on an experimentally induced endometriosis rat model. Study design: After endometriotic implants were surgically formed, rats were randomly divided into 2 groups as control group (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The i...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2013-10, Vol.20 (10), p.1230-1236
Main Authors: Ergenoğlu, Ahmet Mete, Yeniel, Ahmet Özgür, Erbaş, Oytun, Aktuğ, Hüseyin, Yildirim, Nuri, Ulukuş, Murat, Taskiran, Dilek
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Embryology
Endometriosis - drug therapy
Endometriosis - pathology
Endometrium - drug effects
Endometrium - pathology
Female
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original Article
Random Allocation
Rats
Rats, Sprague-Dawley
Remission Induction - methods
Reproductive Medicine
Stilbenes - pharmacology
Stilbenes - therapeutic use
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Summary:Objective: To evaluate the effect of resveratrol on an experimentally induced endometriosis rat model. Study design: After endometriotic implants were surgically formed, rats were randomly divided into 2 groups as control group (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The inflammatory markers and histopathological changes were assessed at the end of the treatment period. Results Our results showed (1) significant reduction in the implant size (P < .0005); (2) significantly decreased levels of vascular endothelial growth factor (VEGF) in the peritoneal fluid and plasma (P < .005); and monocyte chemotactic protein 1 (MCP-1) in the peritoneal fluid (P < .05), (3) highly significant suppression of VEGF expression in the endometriotic tissue (P < .0005); and (4) considerable histological changes in the endometriotic foci following resveratrol treatment. Conclusion: Resveratrol appears to be effective on the development of endometriosis through its antiangiogenic and anti-inflammatory properties. Future studies with different doses of resveratrol might provide more comprehensive results regarding the treatment of endometriosis.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719113483014