Effects of 2-chlorodibenzofuran on fetal development in mice

The contaminant, 2-chlorodibenzofuran (2-MCDF), has been found in drinking water in Japan. In a study of teratogenicity, pregnant mice were exposed to various concentrations of 2-MCDF during organogenesis, from day 6 to day 15 of gestation. Liver weight relative to body weight increased in a dose-de...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1993-11, Vol.51 (5), p.748-755
Main Authors: Usami, M, Sakemi, K, Tabata, H, Kawashima, K, Takanaka, A
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - pathology
AGUA POTABLE
Animals
BAZO
Benzofurans - toxicity
Biological and medical sciences
BODY WEIGHT
Body Weight - drug effects
Bone Development - drug effects
COMPOSE ORGANOCHLORE
COMPUESTO ORGANICO DEL CLORO
CONTAMINANTES
CONTAMINANTS
DESARROLLO DEL ESQUELETO
DESARROLLO EMBRIONARIO
DEVELOPPEMENT DU SQUELETTE
DEVELOPPEMENT EMBRYONNAIRE
DRINKING WATER
EAU POTABLE
Embryology: invertebrates and vertebrates. Teratology
Embryonic and Fetal Development - drug effects
EMBRYONIC DEVELOPMENT
Female
FETAL GROWTH
FOIE
Fundamental and applied biological sciences. Psychology
HALOGENATED HYDROCARBONS
HIDROCARBUROS HALOGENADOS
HIGADO
HYDROCARBURE HALOGENE
LIVER
Male
MICE
Mice, Inbred ICR
Organ Size - drug effects
ORGANOCHLORINE COMPOUNDS
PESO
POIDS
POLLUANT
POLLUTANTS
Pregnancy
RATE
RATON
SKELETAL DEVELOPMENT
SOURIS
SPLEEN
TAP WATER
Teratology. Teratogens
THYMUS (GENERO)
THYMUS (GENRE)
THYMUS (GENUS)
TOXICIDAD
TOXICITE
TOXICITY
WEIGHT
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Description
Summary:The contaminant, 2-chlorodibenzofuran (2-MCDF), has been found in drinking water in Japan. In a study of teratogenicity, pregnant mice were exposed to various concentrations of 2-MCDF during organogenesis, from day 6 to day 15 of gestation. Liver weight relative to body weight increased in a dose-dependent manner in the pregnant females, demonstrating that the doses used were toxic to them. In the fetuses, several gross, visceral, and skeletal malformations were observed, but none were statistically significant. Some skeletal variations were observed, but only the incidence of hypoplastic supraoccipital bones was significant. The no-observable-effect levels for fetal and maternal mice were estimated to be 250 and 125 mg/kg/d, respectively. From this information, an allowable daily 2-MCDF intake for humans, and particularly, pregnant women, is 2.5 mg/d for a 50-kg woman, far higher than amounts that could reasonably be ingested from drinking water.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF00201654