Bioassay screening for toxicants in oil samples from the toxic-oil syndrome outbreak in Spain

A bioassay screening procedure was developed using an agar-plate inhibition assay and applied to a set of 32 oil samples obtained during investigations of the toxic-oil syndrome in Spain. After blind-decoding, it was noted that the assay had singled out the case-associated sample as the most toxic o...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 1985-05, Vol.14 (3), p.261-271
Main Authors: TURNER, W. E, HILL, R. H. JR, HANNON, W. H, BERNERT, J. T. JR, KILBOURNE, E. M, BAYSE, D. D
Format: Article
Language:English
Subjects:
Biological and medical sciences
Disease Outbreaks
Food Contamination - analysis
Food toxicology
Gas Chromatography-Mass Spectrometry
Humans
Medical sciences
Oils - adverse effects
Oils - analysis
Spain
Toxicology
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Summary:A bioassay screening procedure was developed using an agar-plate inhibition assay and applied to a set of 32 oil samples obtained during investigations of the toxic-oil syndrome in Spain. After blind-decoding, it was noted that the assay had singled out the case-associated sample as the most toxic oil from the 32-sample set. Five other oil samples were also selected by the assay. Further evaluation showed that these case-associated, suspect case-associated, and miscellaneous oils had significantly more peroxidation than the controls, as indicated by the thiobarbituric acid assay. The bioassay procedure should be applied to a larger set of epidemiologically documented oils to determine if this screening process can contribute to a better understanding of the toxic-oil syndrome.
ISSN:0090-4341
1432-0703
DOI:10.1007/BF01055402