A Material-Sparing Method for Assessment of Powder Deformation Characteristics Using Data Collected During a Single Compression–Decompression Cycle

• Published in: Journal of pharmaceutical sciences 2013-10, Vol.102 (10), p.3687-3693
• Main Authors: Katz, Jeffrey M., Roopwani, Rahul, Buckner, Ira S.
• Format: Article
• Language: English
• Subjects: Chemistry, Pharmaceutical - methods; compaction; compression; Compressive Strength; Drug Compounding - methods; Excipients - chemistry; materials science; mechanical properties; porosity; Powders - chemistry; Pressure; solid dosage form; tablet; tableting; Tablets - chemistry
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.23676

Compressibility profiles, or functions of solid fraction versus applied pressure, are used to provide insight into the fundamental mechanical behavior of powders during compaction. These functions, collected during compression (in-die) or post ejection (out-of-die), indicate the amount of pressure that a given powder formulation requires to be compressed to a given density or thickness. To take advantage of the benefits offered by both methods, the data collected in-die during a single compression–decompression cycle will be used to generate the equivalent of a complete out-of-die compressibility profile that has been corrected for both elastic and viscoelastic recovery of the powder. This method has been found to be both a precise and accurate means of evaluating out-of-die compressibility for four common tableting excipients. Using this method, a comprehensive characterization of powder compaction behavior, specifically in relation to plastic/brittle, elastic and viscoelastic deformation, can be obtained. Not only is the method computationally simple, but it is also material-sparing. The ability to characterize powder compressibility using this approach can improve productivity and streamline tablet development studies. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:3687–3693, 2013