Sleep disturbances and changes in urinary 6-sulphatoxymelatonin levels in patients with breast cancer undergoing lumpectomy

Background Sleep disturbances and changes in self‐reported discomfort and melatonin secretion are common in the post‐operative period. We aimed to study the distribution of sleep stages in the perioperative period and evaluate changes in secretion of the melatonin metabolite aMT6s and subjective par...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2013-10, Vol.57 (9), p.1146-1153
Main Authors: HANSEN, M. V., MADSEN, M. T., WILDSCHIØDTZ, G., ROSENBERG, J., GÖGENUR, I.
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia, General
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - surgery
Fatigue
Fatigue - etiology
Female
Humans
Insomnia
Mastectomy, Segmental - adverse effects
Melatonin - analogs & derivatives
Melatonin - urine
Menopause - physiology
Middle Aged
Pain
Pain Measurement
Pain, Postoperative - epidemiology
Polysomnography
Postoperative Complications - psychology
Postoperative Complications - urine
Postoperative period
Preanesthetic Medication
Sleep Stages - drug effects
Sleep Wake Disorders - etiology
Sleep, REM - physiology
Surgery
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Summary:Background Sleep disturbances and changes in self‐reported discomfort and melatonin secretion are common in the post‐operative period. We aimed to study the distribution of sleep stages in the perioperative period and evaluate changes in secretion of the melatonin metabolite aMT6s and subjective parameters of sleepiness, pain, general well‐being and fatigue in patients undergoing surgery for breast cancer. Methods Twelve patients, 30–70 years, undergoing lumpectomy were included. Polysomnography was performed the night before surgery (PREOP), the night after (PO1) and 14 days after (PO14). Recordings were scored as awake, light‐sleep, slow‐wave sleep and rapid‐eye‐movement (REM) sleep. Sleep stages were analysed as % of total sleep time (TST). Self‐reported discomfort was assessed using questions about the level of fatigue, well‐being, pain and sleepiness. Urinary aMT6s was measured by radioimmunoassay. Results There was significantly decreased REM sleep on PO1 (5.9% of TST) compared with PREOP (18.7% of TST) (P 
ISSN:0001-5172
1399-6576
DOI:10.1111/aas.12157