White-Matter Connectivity and Methylphenidate-Induced Changes in Attentional Performance According to α2A-Adrenergic Receptor Gene Polymorphisms in Korean Children With Attention-Deficit Hyperactivity Disorder

The authors examined the association between the MspI C/G and DraI C/T genotypes of the α2A-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele a...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 2013, Vol.25 (3), p.222-228
Main Authors: Park, Subin, Hong, Soon-Beom, Kim, Jae-Won, Yang, Young-Hui, Park, Min-Hyeon, Kim, Boong-Nyun, Shin, Min-Sup, Yoo, Hee-Jeong, Cho, Soo-Churl
Format: Article
Language:English
Subjects:
Adolescent
Anisotropy
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - genetics
Attention Deficit Disorder with Hyperactivity - pathology
Biological and medical sciences
Central Nervous System Stimulants - therapeutic use
Child
Diffusion Magnetic Resonance Imaging
Female
Gene Frequency
Genotype
Humans
Male
Medical sciences
Methylphenidate - therapeutic use
Nerve Fibers, Myelinated - pathology
Neuropharmacology
Pharmacology. Drug treatments
Polymorphism, Single Nucleotide - genetics
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Receptors, Adrenergic, alpha-2 - genetics
Republic of Korea
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Summary:The authors examined the association between the MspI C/G and DraI C/T genotypes of the α2A-adrenergic receptor gene and white-matter connectivity and attentional performance before and after medication in 53 children with attention-deficit hyperactivity disorder. Subjects who carried the T allele at the DraI polymorphism showed fewer changes in the mean commission error scores after 8 weeks of medication and decreased fractional anisotropy (FA) values in the right middle frontal cortex than subjects without the T allele. Subjects with the C allele at the MspI polymorphism showed decreased FA values in the right postcentral gyrus than subjects without.
ISSN:0895-0172
1545-7222
DOI:10.1176/appi.neuropsych.12050121