Influence of Dietary Calcium on Chlordecone-Induced Biochemical Changes in Serum of Rat

Male, Sprague-Dawley rats were treated with different (1, 10, 50, and 100 ppm) concentrations of chlordecone (Cd) in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. No significant changes in serum total proteins were observed. However, serum nonprotein nitrogen compounds (ure...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 1993-10, Vol.26 (2), p.248-252
Main Authors: Chetty, K.N., Walker, J., Brown, K., Ivie, G.W.
Format: Article
Language:English
Subjects:
ACIDE URIQUE
ACIDO URICO
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
ALANINA AMINOTRANSFERASA
ALANINE AMINOTRANSFERASE
ALKALINE PHOSPHATASE
Animals
ASPARTATE AMINOTRANSFERASE
ASPARTATO AMINOTRANSFERASA
Biological and medical sciences
Blood Proteins - drug effects
Blood Proteins - metabolism
BLOOD SERUM
CALCIO
CALCIUM
Calcium - blood
Calcium - deficiency
Calcium, Dietary - pharmacology
CHLORDECONE
Chlordecone - blood
Chlordecone - toxicity
CLORDECONE
CREATINA QUINASA
CREATINE KINASE
CREATININA
CREATININE
DEFICIENCY DISEASES
DIET
DIETA
Dose-Response Relationship, Drug
ENFERMEDADES CARENCIALES
ENZYMIC ACTIVITY
EXPOSURE
FOSFATASA ALCALINA
MALADIE DE CARENCE
Male
Medical sciences
Nitrogen Compounds - blood
NUTRIENT DEFICIENCIES
Pesticides, fertilizers and other agrochemicals toxicology
PHOSPHATASE ALCALINE
PROTEINAS
PROTEINE
PROTEINS
RAT
RATA
RATS
Rats, Sprague-Dawley
REGIME ALIMENTAIRE
SERUM SANGUIN
SUERO SANGUINEO
TOXICIDAD
TOXICITE
TOXICITY
Toxicology
UREA
UREE
URIC ACID
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Description
Summary:Male, Sprague-Dawley rats were treated with different (1, 10, 50, and 100 ppm) concentrations of chlordecone (Cd) in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. No significant changes in serum total proteins were observed. However, serum nonprotein nitrogen compounds (urea, uric acid, and creatinine) and glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, creatine kinase, and alkaline phosphatase were significantly increased at 50 and 100 ppm of Cd. Chlordecone induced more increase in these serum components of rats fed with Ca-D as compared to Ca-S diet. Increased serum nonprotein nitrogen compounds and enzymes indicate Cd-altered glomerular and hepatic functions.
ISSN:0147-6513
1090-2414
DOI:10.1006/eesa.1993.1053