Development of an in vitro screening test to evaluate the in vivo bioaccessibility of ingested mine-waste lead

An in vitro test was developed and validated with a feeding study in rabbits to estimate the bioaccessibility of lead (Pb) from mine waste on ingestion. The results indicated that ingestion of Pb-bearing mine wastes results in limited Pb solubility and that the in vitro test provides a screening-lev...

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Bibliographic Details
Published in:Environmental science & technology 1993-12, Vol.27 (13), p.2870-2877
Main Authors: Ruby, Michael V, Davis, Andy, Link, Timothy E, Schoof, Rosalind, Chaney, Rufus L, Freeman, Gary B, Bergstrom, Paul
Format: Article
Language:English
Subjects:
Biological and medical sciences
Children & youth
Environmental pollutants toxicology
General aspects
Lead
Medical sciences
Mining
Rabbits
Soils
Toxicology
Waste materials
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Description
Summary:An in vitro test was developed and validated with a feeding study in rabbits to estimate the bioaccessibility of lead (Pb) from mine waste on ingestion. The results indicated that ingestion of Pb-bearing mine wastes results in limited Pb solubility and that the in vitro test provides a screening-level estimate of the maximum available Pb from mine wastes.
ISSN:0013-936X
1520-5851
DOI:10.1021/es00049a030