Development of an in vitro screening test to evaluate the in vivo bioaccessibility of ingested mine-waste lead

An in vitro test was developed and validated with a feeding study in rabbits to estimate the bioaccessibility of lead (Pb) from mine waste on ingestion. The results indicated that ingestion of Pb-bearing mine wastes results in limited Pb solubility and that the in vitro test provides a screening-lev...

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Published in:Environmental science & technology 1993-12, Vol.27 (13), p.2870-2877
Main Authors: Ruby, Michael V, Davis, Andy, Link, Timothy E, Schoof, Rosalind, Chaney, Rufus L, Freeman, Gary B, Bergstrom, Paul
Format: Article
Language:English
Subjects:
Biological and medical sciences
Children & youth
Environmental pollutants toxicology
General aspects
Lead
Medical sciences
Mining
Rabbits
Soils
Toxicology
Waste materials
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cited_by cdi_FETCH-LOGICAL-a388t-32ecdb8114b997ce35bf366906b1fdbe6fa0d5c2e6001f8ec2b6f7b17b26dd413
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container_end_page 2877
container_issue 13
container_start_page 2870
container_title Environmental science & technology
container_volume 27
creator Ruby, Michael V
Davis, Andy
Link, Timothy E
Schoof, Rosalind
Chaney, Rufus L
Freeman, Gary B
Bergstrom, Paul
description An in vitro test was developed and validated with a feeding study in rabbits to estimate the bioaccessibility of lead (Pb) from mine waste on ingestion. The results indicated that ingestion of Pb-bearing mine wastes results in limited Pb solubility and that the in vitro test provides a screening-level estimate of the maximum available Pb from mine wastes.
doi_str_mv 10.1021/es00049a030
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ispartof Environmental science & technology, 1993-12, Vol.27 (13), p.2870-2877
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1520-5851
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source ACS CRKN Legacy Archives
subjects Biological and medical sciences
Children & youth
Environmental pollutants toxicology
General aspects
Lead
Medical sciences
Mining
Rabbits
Soils
Toxicology
Waste materials
title Development of an in vitro screening test to evaluate the in vivo bioaccessibility of ingested mine-waste lead
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