Surgical treatment for non-small cell lung cancer with ipsilateral pulmonary metastases

• Published in: Surgery today (Tokyo, Japan) Japan), 2013-10, Vol.43 (10), p.1123-1128
• Main Authors: Okamoto, Tatsuro, Iwata, Takekazu, Mizobuchi, Teruaki, Hoshino, Hidehisa, Moriya, Yasumitsu, Yoshida, Shigetoshi, Yoshino, Ichiro
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - secondary; Carcinoma, Non-Small-Cell Lung - surgery; Female; Humans; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Original Article; Pneumonectomy; Retrospective Studies; Surgery; Surgical Oncology; Survival Rate; Time Factors; Treatment Outcome; Young Adult
• ISSN: 0941-1291; 1436-2813
• DOI: 10.1007/s00595-012-0452-x

Purpose The aim of this retrospective study was to evaluate the relevance of surgery in non-small cell lung cancer (NSCLC) patients with ipsilateral pulmonary metastases. Methods The clinical records of 1,623 consecutive NSCLC patients who underwent surgery between 1990 and 2007 were retrospectively reviewed. Overall, 161 (9.9 %) and 21 (1.3 %) patients had additional nodules in the same lobe as the primary lesion (PM1) and additional nodules in the ipsilateral different lobe (PM2), respectively. Results The 5-year survival rate was 54.4 % in the PM1 patients and 19.3 % in the PM2 patients (log-rank test: p  = 0.001). Tumor size ≤3 cm, N0-1 status and surgical procedures less extensive than bilobectomy were identified as favorable prognostic factors in the PM1 patients. The 5-year survival rate in the PM1-N0-1 patients was 68.7 %, while that in the PM1-N2-3 patients was 29.1 % ( p