Loading…
Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis
Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti‐infl...
Saved in:
| Published in: | ChemMedChem 2013-09, Vol.8 (9), p.1462-1464 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13 |
| container_end_page | 1464 |
| container_issue | 9 |
| container_start_page | 1462 |
| container_title | ChemMedChem |
| container_volume | 8 |
| creator | Zhai, Jing Zhang, Hong Zhang, Ligping Zhao, Yining Chen, Sangke Chen, Yunyun Peng, Xinyu Li, Qing Yuan, Minggui Hu, Xiaopeng |
| description | Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti‐inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles. |
| doi_str_mv | 10.1002/cmdc.201300243 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1433266350</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1433266350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13</originalsourceid><addsrcrecordid>eNqFkLtOw0AQRVcIREKgpURb0jjsy48tiSGOpQQKgpBoVmN7Iwx2HHZtkXQ0_ChfgiOHiI5qZqRzr0YHoXNKhpQQdpWWWTpkhPL2EPwA9WngEcengX-4333ZQyfWvhIiRECDY9RjPHB9KVgfTZ6rVVUYbWuoMVgMeNKUsMRRsanWUIDV359fMY6XL3mS15XBsMxwXFv8UJsmrRsDBR6Bze0pOlpAYfXZbg7Q4_h2Hk6c6X0Uh9dTJ-We4I4gjDImFy5xE86J9Bcs81zuS-2lXEsJzJVEAKWSatH-TzPBIUhcQjSjGVA-QJdd78pU7037typzm-qigKWuGquo4Jx5HndJiw47NDWVtUYv1MrkJZiNokRt7amtPbW31wYudt1NUupsj__qagHZAR95oTf_1KlwdhP-LXe6bG5rvd5nwbwpz-e-q57uIhWNR2w8i-Yq5D9Wcokq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1433266350</pqid></control><display><type>article</type><title>Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Zhai, Jing ; Zhang, Hong ; Zhang, Ligping ; Zhao, Yining ; Chen, Sangke ; Chen, Yunyun ; Peng, Xinyu ; Li, Qing ; Yuan, Minggui ; Hu, Xiaopeng</creator><creatorcontrib>Zhai, Jing ; Zhang, Hong ; Zhang, Ligping ; Zhao, Yining ; Chen, Sangke ; Chen, Yunyun ; Peng, Xinyu ; Li, Qing ; Yuan, Minggui ; Hu, Xiaopeng</creatorcontrib><description>Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti‐inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles.</description><identifier>ISSN: 1860-7179</identifier><identifier>EISSN: 1860-7187</identifier><identifier>DOI: 10.1002/cmdc.201300243</identifier><identifier>PMID: 23857942</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - metabolism ; Benzothiazoles - chemistry ; Benzothiazoles - metabolism ; Binding Sites ; crystal structures ; Crystallography, X-Ray ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - metabolism ; glyoxalase I ; Humans ; indomethacin ; Indomethacin - chemistry ; Indomethacin - metabolism ; inhibitors ; Lactoylglutathione Lyase - chemistry ; Lactoylglutathione Lyase - metabolism ; Mice ; Phthalazines - chemistry ; Phthalazines - metabolism ; Protein Binding ; Protein Structure, Tertiary ; zinc metalloenzymes ; zopolrestat</subject><ispartof>ChemMedChem, 2013-09, Vol.8 (9), p.1462-1464</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13</citedby><cites>FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23857942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhai, Jing</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Zhang, Ligping</creatorcontrib><creatorcontrib>Zhao, Yining</creatorcontrib><creatorcontrib>Chen, Sangke</creatorcontrib><creatorcontrib>Chen, Yunyun</creatorcontrib><creatorcontrib>Peng, Xinyu</creatorcontrib><creatorcontrib>Li, Qing</creatorcontrib><creatorcontrib>Yuan, Minggui</creatorcontrib><creatorcontrib>Hu, Xiaopeng</creatorcontrib><title>Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis</title><title>ChemMedChem</title><addtitle>ChemMedChem</addtitle><description>Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti‐inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - metabolism</subject><subject>Benzothiazoles - chemistry</subject><subject>Benzothiazoles - metabolism</subject><subject>Binding Sites</subject><subject>crystal structures</subject><subject>Crystallography, X-Ray</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - metabolism</subject><subject>glyoxalase I</subject><subject>Humans</subject><subject>indomethacin</subject><subject>Indomethacin - chemistry</subject><subject>Indomethacin - metabolism</subject><subject>inhibitors</subject><subject>Lactoylglutathione Lyase - chemistry</subject><subject>Lactoylglutathione Lyase - metabolism</subject><subject>Mice</subject><subject>Phthalazines - chemistry</subject><subject>Phthalazines - metabolism</subject><subject>Protein Binding</subject><subject>Protein Structure, Tertiary</subject><subject>zinc metalloenzymes</subject><subject>zopolrestat</subject><issn>1860-7179</issn><issn>1860-7187</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOw0AQRVcIREKgpURb0jjsy48tiSGOpQQKgpBoVmN7Iwx2HHZtkXQ0_ChfgiOHiI5qZqRzr0YHoXNKhpQQdpWWWTpkhPL2EPwA9WngEcengX-4333ZQyfWvhIiRECDY9RjPHB9KVgfTZ6rVVUYbWuoMVgMeNKUsMRRsanWUIDV359fMY6XL3mS15XBsMxwXFv8UJsmrRsDBR6Bze0pOlpAYfXZbg7Q4_h2Hk6c6X0Uh9dTJ-We4I4gjDImFy5xE86J9Bcs81zuS-2lXEsJzJVEAKWSatH-TzPBIUhcQjSjGVA-QJdd78pU7037typzm-qigKWuGquo4Jx5HndJiw47NDWVtUYv1MrkJZiNokRt7amtPbW31wYudt1NUupsj__qagHZAR95oTf_1KlwdhP-LXe6bG5rvd5nwbwpz-e-q57uIhWNR2w8i-Yq5D9Wcokq</recordid><startdate>201309</startdate><enddate>201309</enddate><creator>Zhai, Jing</creator><creator>Zhang, Hong</creator><creator>Zhang, Ligping</creator><creator>Zhao, Yining</creator><creator>Chen, Sangke</creator><creator>Chen, Yunyun</creator><creator>Peng, Xinyu</creator><creator>Li, Qing</creator><creator>Yuan, Minggui</creator><creator>Hu, Xiaopeng</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis</title><author>Zhai, Jing ; Zhang, Hong ; Zhang, Ligping ; Zhao, Yining ; Chen, Sangke ; Chen, Yunyun ; Peng, Xinyu ; Li, Qing ; Yuan, Minggui ; Hu, Xiaopeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - metabolism</topic><topic>Benzothiazoles - chemistry</topic><topic>Benzothiazoles - metabolism</topic><topic>Binding Sites</topic><topic>crystal structures</topic><topic>Crystallography, X-Ray</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - metabolism</topic><topic>glyoxalase I</topic><topic>Humans</topic><topic>indomethacin</topic><topic>Indomethacin - chemistry</topic><topic>Indomethacin - metabolism</topic><topic>inhibitors</topic><topic>Lactoylglutathione Lyase - chemistry</topic><topic>Lactoylglutathione Lyase - metabolism</topic><topic>Mice</topic><topic>Phthalazines - chemistry</topic><topic>Phthalazines - metabolism</topic><topic>Protein Binding</topic><topic>Protein Structure, Tertiary</topic><topic>zinc metalloenzymes</topic><topic>zopolrestat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhai, Jing</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Zhang, Ligping</creatorcontrib><creatorcontrib>Zhao, Yining</creatorcontrib><creatorcontrib>Chen, Sangke</creatorcontrib><creatorcontrib>Chen, Yunyun</creatorcontrib><creatorcontrib>Peng, Xinyu</creatorcontrib><creatorcontrib>Li, Qing</creatorcontrib><creatorcontrib>Yuan, Minggui</creatorcontrib><creatorcontrib>Hu, Xiaopeng</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ChemMedChem</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhai, Jing</au><au>Zhang, Hong</au><au>Zhang, Ligping</au><au>Zhao, Yining</au><au>Chen, Sangke</au><au>Chen, Yunyun</au><au>Peng, Xinyu</au><au>Li, Qing</au><au>Yuan, Minggui</au><au>Hu, Xiaopeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis</atitle><jtitle>ChemMedChem</jtitle><addtitle>ChemMedChem</addtitle><date>2013-09</date><risdate>2013</risdate><volume>8</volume><issue>9</issue><spage>1462</spage><epage>1464</epage><pages>1462-1464</pages><issn>1860-7179</issn><eissn>1860-7187</eissn><abstract>Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti‐inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>23857942</pmid><doi>10.1002/cmdc.201300243</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1860-7179 |
| ispartof | ChemMedChem, 2013-09, Vol.8 (9), p.1462-1464 |
| issn | 1860-7179 1860-7187 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1433266350 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - metabolism Benzothiazoles - chemistry Benzothiazoles - metabolism Binding Sites crystal structures Crystallography, X-Ray Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism glyoxalase I Humans indomethacin Indomethacin - chemistry Indomethacin - metabolism inhibitors Lactoylglutathione Lyase - chemistry Lactoylglutathione Lyase - metabolism Mice Phthalazines - chemistry Phthalazines - metabolism Protein Binding Protein Structure, Tertiary zinc metalloenzymes zopolrestat |
| title | Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T19%3A12%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zopolrestat%20as%20a%20Human%20Glyoxalase%E2%80%85I%20Inhibitor%20and%20Its%20Structural%20Basis&rft.jtitle=ChemMedChem&rft.au=Zhai,%20Jing&rft.date=2013-09&rft.volume=8&rft.issue=9&rft.spage=1462&rft.epage=1464&rft.pages=1462-1464&rft.issn=1860-7179&rft.eissn=1860-7187&rft_id=info:doi/10.1002/cmdc.201300243&rft_dat=%3Cproquest_cross%3E1433266350%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3643-4021229f505b33097f2d65379e6c3e99a25904a1191e41861d43a8b500e21da13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1433266350&rft_id=info:pmid/23857942&rfr_iscdi=true |