Influence of gestational diabetes on circadian rhythms of children and their association with fetal adiposity

Objective To analyse the circadian rhythm maturation of temperature, activity and sleep during the first year of life in offspring of diabetic mothers (ODM) and its relationship with obesity markers. Methods A prospective analysis of the children of 63 pregnant women (23 controls, 21 gestational dia...

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Published in:Diabetes/metabolism research and reviews 2013-09, Vol.29 (6), p.483-491
Main Authors: Zornoza-Moreno, Matilde, Fuentes-Hernández, Silvia, Prieto-Sánchez, María T., Blanco, José E., Pagán, Ana, Rol, María-Ángeles, Parrilla, Juan J., Madrid, Juan A., Sánchez-Solis, Manuel, Larqué, Elvira
Format: Article
Language:English
Subjects:
Adiposity - physiology
Adolescent
Adult
Birth Weight - physiology
Case-Control Studies
Circadian Rhythm - physiology
circadian rhythms
Diabetes, Gestational - physiopathology
Female
fetal adiposity
Fetus - physiopathology
gestational diabetes
Humans
Infant
Infant, Newborn
macrosomia
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - physiopathology
Young Adult
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Summary:Objective To analyse the circadian rhythm maturation of temperature, activity and sleep during the first year of life in offspring of diabetic mothers (ODM) and its relationship with obesity markers. Methods A prospective analysis of the children of 63 pregnant women (23 controls, 21 gestational diabetes mellitus (GDM) controlled with diet and 19 GDM with insulin). Fetal abdominal circumference was evaluated ecographically during gestation. Skin temperature and rest‐activity rhythms were monitored for 3 consecutive days in children at 15 days and 1, 3 and 6 months. Anthropometrical parameters of the children were evaluated during the first year of life. Results Children from the GDM groups tended to higher fetal abdominal circumference z‐score than controls at the beginning of the last trimester (p = 0.077) and at delivery (p = 0.078). Mean skin temperature or activity was not different among the groups. The I 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.2417