Assessment of cellular reactions to magnesium as implant 
material in comparison to titanium and to glyconate using 
the mouse tail model

Nowadays, research in magnesium alloys as a biodegradable implant material has increased. The aim of this study was to examine osteoinductive properties and tissue responses to pure magnesium in comparison to conventional permanent (titanium) and to degradable (glyconate) implant materials. Magnesiu...

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Bibliographic Details
Published in:Journal of applied biomaterials & functional materials 2013-09, Vol.11 (2), p.e89-94
Main Authors: Reifenrath, Janin, Badar, Muhammad, Dziuba, Dina, Müller, Peter P, Heidenblut, Torsten, Bondarenko, Alexander, Meyer-Lindenberg, Andrea
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Bone Wires
Cells - drug effects
Female
Gluconates - pharmacology
Magnesium - pharmacology
Materials Testing
Mice
Mice, Inbred BALB C
Models, Biological
Osseointegration - drug effects
Osseointegration - physiology
Prostheses and Implants
Tail
Titanium - pharmacology
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Summary:Nowadays, research in magnesium alloys as a biodegradable implant material has increased. The aim of this study was to examine osteoinductive properties and tissue responses to pure magnesium in comparison to conventional permanent (titanium) and to degradable (glyconate) implant materials. Magnesium wires (0.4 mm in diameter, 10 mm length) were implanted into tail veins of mice and examined after 2, 4, 8, 16 and 32 weeks. Titanium and glyconate as controls were assessed after 2, 4, 8 and 24 weeks. µ-computed tompgraphy, histology and SEM examinations were performed. Magnesium implants showed increasing structural losses over time with fragmentation after an observation period of 32 weeks. Glyconate was fully degraded and titanium remained almost unaffected after 24 weeks. In contrast to some titanium and glyconate implants, first calcium and phosphate precipitations could be observed around magnesium implants after two weeks. However, ossification could not be observed even after 32 weeks, whereas enchondral ossification was found partially in the sourrounding of glyconate and titanium implants after eight weeks. Nevertheless, magnesium implants showed less inflammatory responses and fibrosing properties than the conventional implant materials. Although the assumed osteoinductive properties could not be detected, magnesium appears to be a promising degradable implant material because of the low sensitizing and inflammatory potential.
ISSN:2280-8000
2280-8000
DOI:10.5301/jabfm.5000150