Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients

Metabolic syndrome (MetS) is associated with high oxidative stress, which is caused by an increased expression of NADPH-oxidase and a decreased expression of antioxidant enzymes in the adipose tissue. Our aim was to evaluate whether the quality and quantity of dietary fat can modify that process. A...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2013-10, Vol.24 (10), p.1717-1723
Main Authors: Peña-Orihuela, Patricia, Camargo, Antonio, Rangel-Zuñiga, Oriol Alberto, Perez-Martinez, Pablo, Cruz-Teno, Cristina, Delgado-Lista, Javier, Yubero-Serrano, Elena M, Paniagua, Juan A, Tinahones, Francisco J, Malagon, Maria M, Roche, Helen M, Perez-Jimenez, Francisco, Lopez-Miranda, Jose
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - enzymology
Antioxidant enzymes
Antioxidants - metabolism
Catalase - metabolism
Diet
dietary fat
Dietary Fats - pharmacology
Dietary Fats, Unsaturated - pharmacology
fat intake
fatty acid composition
Fatty Acids, Monounsaturated - pharmacology
Fatty Acids, Omega-3 - pharmacology
Glutathione Peroxidase - metabolism
Humans
LIPGENE study
Membrane Glycoproteins - metabolism
messenger RNA
Metabolic syndrome
Metabolic Syndrome - physiopathology
Middle Aged
NADPH Oxidase 2
NADPH Oxidases - metabolism
NF-E2-Related Factor 2 - metabolism
Oxidative stress
Oxidative Stress - drug effects
patients
Phosphoproteins - metabolism
polyunsaturated fatty acids
Postprandial Period
RNA, Messenger - metabolism
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Summary:Metabolic syndrome (MetS) is associated with high oxidative stress, which is caused by an increased expression of NADPH-oxidase and a decreased expression of antioxidant enzymes in the adipose tissue. Our aim was to evaluate whether the quality and quantity of dietary fat can modify that process. A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to one of four diets for 12 wk each: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) and (iv) two low-fat, high-complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids (LFHCC n3), or placebo (LFHCC). A fat challenge reflecting the same fatty acid composition as the original diets was conducted post-intervention. The intake of an HSFA meal induced a higher postprandial increase in gp91phox and p67phox mRNA levels than after the intake of HMUFA, LFHCC and LFHCC n-3 meals (all p-values
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2013.02.012