Effect of the Reduction of Skin Contamination on the Internal Dose of Creosote Workers Exposed to Polycyclic Aromatic Hydrocarbons

Ten creosote-exposed workers of a wood impregnation plant participated in this study, which took place in two consecutive weeks on a Monday, after a weekend off. On one of the two days each worker wore Tyvek® coveralls underneath his normal workclothes. Dermal contamination measurements (pyrene on e...

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Bibliographic Details
Published in:Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1993-06, Vol.19 (3), p.ix+200-207
Main Authors: Van Rooij, Joost GM, Van Lieshout, Eugenie MA, Bodelier-Bade, Monika M, Jongeneelen, Frans J
Format: Article
Language:English
Subjects:
Adult
Air
Biological and medical sciences
Breath Tests
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical hazards
Coveralls
Creosote
Cylinders
Dosage
Excretion
Humans
Medical sciences
Middle Aged
Occupational Diseases - chemically induced
Occupational Diseases - prevention & control
Occupational Exposure
Polycyclic aromatic hydrocarbons
Protective Clothing
Pyrenes - adverse effects
Pyrenes - pharmacokinetics
Regression Analysis
Skin
Skin - drug effects
Skin - metabolism
Skin Diseases - chemically induced
Skin Diseases - prevention & control
Time Factors
Toxicology
Urine
Various organic compounds
Wood
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Summary:Ten creosote-exposed workers of a wood impregnation plant participated in this study, which took place in two consecutive weeks on a Monday, after a weekend off. On one of the two days each worker wore Tyvek® coveralls underneath his normal workclothes. Dermal contamination measurements (pyrene on exposure pads) and biological monitoring (urinary 1-OH-pyrene) were performed to measure the reduction of both the skin contamination and the internal dose. The total pyrene skin contamination of workers not wearing coveralls ranged between 47 and 1510 µg · d⁻¹ (0.2— 7.5 µmol · d⁻¹). On the average, the coveralls reduced the pyrene contamination on the workers' skin by about 35 (SD 63)%. The excreted amount of 1-OH-pyrene in urine decreased significantly from 6.6 to 3.2 µg (30.2 to 14.7 nmol). Multiple regression analysis showed that skin contamination by polycylic aromatic hydrocarbons is the main determinant of the internal exposure dose of creosote workers.
ISSN:0355-3140
1795-990X
DOI:10.5271/sjweh.1322