Effect of Uremia and Hemodialysis on Proteome Profile of Blood Platelets and Plasma

The aim of the present research was to assess the differences in blood platelet and plasma proteome profiles of patients with uremia in comparison with healthy participants. It was found that 23 peptides in the platelet proteome profiles of hemodialyzed patients and only 6 peptides in nondialyzed pa...

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Bibliographic Details
Published in:Clinical and applied thrombosis/hemostasis 2013-09, Vol.19 (5), p.541-549
Main Authors: Walkowiak, Bogdan, Sobol, Anna B., Walczynska, Marta, Kaminska, Marta
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Blood platelets
Blood Platelets - metabolism
Case-Control Studies
Female
Hemodialysis
Humans
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - therapy
Kidney Failure, Chronic - urine
Male
Middle Aged
Peptides
Proteome - metabolism
Renal Dialysis
Uremia - blood
Uremia - urine
Young Adult
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Summary:The aim of the present research was to assess the differences in blood platelet and plasma proteome profiles of patients with uremia in comparison with healthy participants. It was found that 23 peptides in the platelet proteome profiles of hemodialyzed patients and only 6 peptides in nondialyzed patients were upregulated. On the other hand, 18 peptides with reduced expression in nondialyzed patients and only 1 peptide in hemodialyzed patients were found. For serum, only 6 upregulated peptides in patients undergoing hemodialysis and 15 peptides in nondialyzed patients were found, most of these were about 10 kDa. A decrease in serum peptide expression was not observed. In conclusion, it should be noted that the process of hemodialysis modifies the platelet proteome to a greater extent than uremia alone, however the sera of nondialyzed patients have much larger amounts of low-molecular-weight peptides than those of hemodialyzed patients.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029612444004