Arborine and methaqualone are not sedative in the wolf spider Lycosa ceratiola Gertsch and Wallace

Glomerin and homoglomerin, two quinazolinone alkaloids in the defensive secretion of the pill milliped, Glomeris marginata , produce delayed sedation of prolonged duration in wolf spiders (Lycosa spp.). The compounds are sedative at small doses (1-7 mu g per spider), representing but a fraction of t...

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Bibliographic Details
Published in:The Journal of arachnology 1985-01, Vol.13 (2), p.269-271
Main Authors: Carrel, J.E, Doom, J.P, McCormick, J.P
Format: Article
Language:English
Subjects:
ALCALOIDE
ALCALOIDES
Alcohols
ALKALOIDS
ARAIGNEE
ARANAS
Biochemistry
COMPOSICION
COMPOSITION
Dosage
DRUGS
FARMACOLOGIA
Hypnotics
Lycosidae
MEDICAMENT
MEDICAMENTOS
PHARMACOLOGIE
PHARMACOLOGY
PLANTAS
PLANTE
PLANTS
Psychotropics
Research Notes
Sedatives
Spider webs
SPIDERS
Wolves
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Summary:Glomerin and homoglomerin, two quinazolinone alkaloids in the defensive secretion of the pill milliped, Glomeris marginata , produce delayed sedation of prolonged duration in wolf spiders (Lycosa spp.). The compounds are sedative at small doses (1-7 mu g per spider), representing but a fraction of the total secretory output of a medium sized milliped. Glomerin and homoglomerin are structurally related to arborine, a plant natural product, and to methaqualone, a synthetic drug. Both arborine and methaqualone are sedative to vertebrates, which suggests that they might also be sedative to spiders. The authors here present evidence indicating that this hypothesis is incorrect, since neither arborine nor methaqualone given in large doses produced sedation (= hypnosis) in the wolf spider, Lycosa ceratiola Gertsch Wallace.
ISSN:0161-8202
1937-2396