Isoindolones from Lasiosphaera fenzlii Reich. and Their Bioactivities

Two new, 1 and 2, along with one known isoindolone, 3, were isolated from the AcOEt extract of Lasiosphaera fenzlii Reich. The structures of these compounds were determined as 4,6‐dihydroxy‐1H‐isoindole‐1,3(2H)‐dione (1), 4,6‐dihydroxy‐2,3‐dihydro‐1H‐isoindol‐1‐one (2), and clitocybin A (3) on the b...

Full description

Saved in:
Bibliographic Details
Published in:Helvetica chimica acta 2013-01, Vol.96 (1), p.109-113
Main Authors: Lü, Wen-Wen, Gao, Yun-Jia, Su, Ming-Zhi, Luo, Zhou, Zhang, Wei, Shi, Guo-Bing, Zhao, Qing-Chun
Format: Article
Language:English
Subjects:
Angiogenesis
Blood vessels
Cytotoxic activity
Isoindolones
Lasiosphaera fenzlii
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new, 1 and 2, along with one known isoindolone, 3, were isolated from the AcOEt extract of Lasiosphaera fenzlii Reich. The structures of these compounds were determined as 4,6‐dihydroxy‐1H‐isoindole‐1,3(2H)‐dione (1), 4,6‐dihydroxy‐2,3‐dihydro‐1H‐isoindol‐1‐one (2), and clitocybin A (3) on the basis of chemical and spectroscopic evidences. The bioactivity assays revealed that all of them were devoid of significant cytotoxicities against tumor cells, whereas 1 exhibited potent antiangiogenic activity by inhibiting the secretion of vascular endothelial growth factor (VEGF) in A549 cells.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201200279