Two New Lycopodium Alkaloids from Lycopodium obscurum

Two new Lycopodium alkaloids, (+)‐cermizine D N‐oxide (1) and (8β)‐8‐(acetyloxy)obscurumine A (2), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All...

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Bibliographic Details
Published in:Helvetica chimica acta 2013-06, Vol.96 (6), p.1197-1201
Main Authors: Pan, Ke, Luo, Jian-Guang, Kong, Ling-Yi
Format: Article
Language:English
Subjects:
(+)-Cermizine D N-oxide
8β-acetoxy
Acetylcholine esterase (AChE)
Alkaloids
Beta
Inhibitors
Lycopodium
Lycopodium obscurum
Obscurumine A
Obscurumine A, 8β‐acetoxy
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Summary:Two new Lycopodium alkaloids, (+)‐cermizine D N‐oxide (1) and (8β)‐8‐(acetyloxy)obscurumine A (2), along with five known compounds, were isolated from the crude alkaloid portion of Lycopodium obscurum. Their structures were elucidated on the basis of spectroscopic data and chemical correlation. All of these alkaloids were tested in an assay for acetylcholine esterase (AChE) inhibitory activity.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201200505