Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132

Two new 6,8(14),22‐hexadehydro‐5α,9α‐epidioxy‐3,15‐dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA‐132, an endophytic fungus isolated from a fre...

Full description

Saved in:
Bibliographic Details
Published in:Helvetica chimica acta 2013-06, Vol.96 (6), p.1055-1061
Main Authors: Liu, Dong, Li, Xiao-Ming, Li, Chun-Shun, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Antiproliferative activity
Aspergillus niger
Aspergillus niger MA-132
Avicennia marina
Fungi
Nigerasterols A and B
Sterols
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new 6,8(14),22‐hexadehydro‐5α,9α‐epidioxy‐3,15‐dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA‐132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9‐epidioxy‐sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201200332