Comparisons of multi b-value DWI signal analysis with pathological specimen of breast cancer

• Published in: Magnetic resonance in medicine 2012-09, Vol.68 (3), p.890-897
• Main Authors: Tamura, Takayuki, Usui, Shuji, Murakami, Shigeru, Arihiro, Koji, Fujimoto, Takashi, Yamada, Tamaki, Naito, Kumiko, Akiyama, Mitoshi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Algorithms; apparent diffusion coefficient; biexponential signal attenuation; breast cancer; Breast Neoplasms - pathology; component fraction; Diffusion Magnetic Resonance Imaging - methods; diffusion weighted imaging; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.23277

Previous studies have reported that the signal attenuation of diffusion weighted magnetic resonance imaging for tumor tissues displays a non‐monoexponential biexponential decay, and the apparent diffusion coefficients (ADCs) can be divided into a fast and slow diffusion component by using a simple biexponential decay model. The purpose of this study is to examine the non‐monoexponential character of the diffusion weighted magnetic resonance imaging signal attenuations of breast cancers, estimate the fast and slow diffusion components, and compare them with the extra‐ and intracellular component information obtained from the pathological specimens. Twenty‐two subjects having breast cancers underwent diffusion weighted magnetic resonance imaging using six b‐values up to 3500 s/mm2 and the signal attenuations were analyzed using the biexponential function. The derived slow component fraction correlated with the cellular fraction and the ADCs converged to 0.2−0.3 × 10−3 mm2/s for the higher cellular fractions. The ADCs of the fast component ranged from 1.3 to 3.9 × 10−3 mm2/s and showed no correlation with the extracellular components. This result suggests that the main reason for the decreasing ADC of a breast tumor is the decreasing fraction of the fast component and the increasing fraction of the slow component having a low ADC rather than the decreasing ADC of the fast component by the restricted water diffusion in the reduced extracellular spaces. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.