Risk of epithelial ovarian cancer in asymptomatic women with ultrasound‐detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS)

• Published in: Ultrasound in obstetrics & gynecology 2012-09, Vol.40 (3), p.338-344
• Main Authors: Sharma, A., Apostolidou, S., Burnell, M., Campbell, S., Habib, M., Gentry‐Maharaj, A., Amso, N., Seif, M. W., Fletcher, G., Singh, N., Benjamin, E., Brunell, C., Turner, G., Rangar, R., Godfrey, K., Oram, D., Herod, J., Williamson, K., Jenkins, H., Mould, T., Woolas, R., Murdoch, J., Dobbs, S., Leeson, S., Cruickshank, D., Fourkala, E.‐O., Ryan, A., Parmar, M., Jacobs, I., Menon, U.
• Format: Article
• Language: English
• Subjects: Adnexa Uteri - abnormalities; Adnexa Uteri - diagnostic imaging; Aged; Biological and medical sciences; borderline ovarian cancer; Carcinoma, Ovarian Epithelial; Cohort Studies; Early Detection of Cancer - methods; Female; Female genital diseases; Follow-Up Studies; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Middle Aged; Neoplasms, Glandular and Epithelial - diagnostic imaging; Neoplasms, Glandular and Epithelial - epidemiology; Ovarian cancer; ovarian cancer screening; ovarian cysts; ovarian neoplasm; Ovarian Neoplasms - diagnostic imaging; Ovarian Neoplasms - epidemiology; Ovary - diagnostic imaging; postmenopausal women; Postmenopause; Prevalence; Prospective Studies; risk; Risk Factors; Tumors; Type I/II epithelial ovarian cancer; UKCTOCS; Ultrasonography; ultrasound; United Kingdom - epidemiology
• ISSN: 0960-7692; 1469-0705
• DOI: 10.1002/uog.12270

Objective To estimate the risk of primary epithelial ovarian cancer (EOC) and slow growing borderline or Type I and aggressive Type II EOC in postmenopausal women with adnexal abnormalities on ultrasound. Methods This was a prospective cohort study in the ultrasound group of the UK Collaborative Trial of Ovarian Cancer Screening of postmenopausal women with ultrasound‐detected abnormal adnexal (unilocular, multilocular, unilocular solid and multilocular solid, solid) morphology on their first scan. Women were followed up through the national cancer registries and by postal questionnaires. Absolute risks of EOC and borderline, Type I and Type II EOC within 3 years of initial scan were calculated. Results Of 48 053 women who underwent ultrasound examination and had complete scan data, 4367 (9.1% (95% CI, 8.8–9.3%)) had abnormal adnexal morphology. Median follow‐up was 7.09 (25th–75th centiles, 6.03–7.92) years. Forty‐seven (32 borderline or Type I, 15 Type II) were diagnosed with EOC. The overall absolute risk of EOC associated with abnormal adnexal morphology was 1.08% (95% CI, 0.79–1.43%); for borderline and Type I it was 0.73% (95% CI, 0.5–1.03%); and for Type II it was 0.34% (95% CI, 0.33–0.79%). In the subgroup (n = 741) with solid elements (unilocular solid, multilocular solid and solid) overall absolute risk was 4.45% (95% CI, 3.08–6.20%), for borderline and Type I it was 3.1% (95% CI, 1.9–4.6%) and for Type II it was 1.3% (95% CI, 0.6–2.4%). 11 982 women had both ovaries visualized and normal annual scans throughout the 3‐year follow‐up period. In this group, no borderline or Type I and eight Type II cancers were diagnosed. Conclusion Asymptomatic postmenopausal women with ultrasound‐detected adnexal abnormalities with solid elements have a 1 in 22 risk for EOC. Despite the higher prevalence of Type II EOC, the risk of borderline or Type I cancer in women with ultrasound abnormalities seems to be higher than does the risk of Type II cancer. This has important immediate implications for patients with incidental adnexal findings as well as for any future ultrasound‐based screening. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.