Association of methylenetetrahydrofolate reductase polymorphisms with susceptibility to Alzheimer's disease

Abstract Background Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). In this case-control study, we examined the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and their correlation with this pathology. Objectiv...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2013-09, Vol.115 (9), p.1693-1696
Main Authors: Mansouri, Leila, Fekih-Mrissa, Najiba, Klai, Sarra, Mansour, Malek, Gritli, Nasreddine, Mrissa, Ridha
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Alcohol use
Alleles
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer's disease
Confidence intervals
Dementia
Deoxyribonucleic acid
Diabetes
DNA
DNA methylation
Enzymes
Family medical history
Female
Gene Frequency
Genes
Genetic Predisposition to Disease
Genotype
Homocysteine
Homocysteine - blood
Human
Humans
Hypertension
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
MTHFR protein
Mutation
Mutation - genetics
Mutation - physiology
Mutation, Missense - genetics
Neurology
Neurosurgery
Patients
Polymorphism, Genetic - genetics
Risk factor
Risk Factors
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Summary:Abstract Background Genetic risk factors play an important role in the pathogenesis of Alzheimer's disease (AD). In this case-control study, we examined the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and their correlation with this pathology. Objective To verify the association between MTHFR C677T and A1298C polymorphisms and Alzheimer's disease. Method This work was conducted as a case–control study. Cases consisted of thirty-eight patients and 100 individuals without dementia constituted the control group. Genotyping of MTHFR polymorphisms was performed on patients and controls. Result Genetic analyses did not indicate a significant association between the MTHFR C677T mutation and AD (C/T: 63.15% versus 39%, p = 0.087). However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p < 10−3 ). Our data suggest an association between the MTHFR A1298C mutation and AD; however, the MTHFR C677T mutation did not contribute to susceptibility for AD. Conclusion The MTHFR A1298C polymorphism is a possible risk factor for Alzheimer's disease.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2013.03.015