Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats

• Published in: Human & experimental toxicology 2012-07, Vol.31 (7), p.676-685
• Main Authors: Adaramoye, OA, Adesanoye, OA, Adewumi, OM, Akanni, O
• Format: Article
• Language: English
• Subjects: Alanine; Animals; Anti-HIV Agents - toxicity; Antiretroviral drugs; Bilirubin - blood; Kidney - anatomy & histology; Kidney - drug effects; Kidney - metabolism; Kidneys; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Males; Malondialdehyde - metabolism; Nevirapine - toxicity; Organ Size - drug effects; Oxidative Stress - drug effects; Pharmacology; Rats; Rats, Wistar; Reproductive system; Rodents; Sperm Count; Sperm Motility - drug effects; Spermatozoa - abnormalities; Spermatozoa - drug effects; Spermatozoa - physiology; Testis - anatomy & histology; Testis - drug effects; Testis - metabolism; Toxicity; Transferases - blood
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1177/0960327111424304

We investigated the toxic effect of nevirapine (NVP; Viramune®), an antiretroviral drug, on the liver, kidney and testis of Wistar rats. Twenty-one rats were assigned into 3 groups of 7 animals each. The first group served as control, and the second and third groups received NVP at 18 and 36 mg/kg body weight, respectively. Clinical signs of toxicity were not observed in the animals. NVP at both doses did not significantly (p > 0.05) alter the body weight gain, relative weights of kidney and testis, serum protein, urea, creatinine and alkaline phosphatase levels of the animals. However, NVP2 significantly (p