Changes in aberrant DNA methylation after Helicobacter pylori eradication: A long‐term follow‐up study

Changes of DNA methylation in gastric mucosae after eradication of Helicobacter pylori have not been clarified yet. From this background, we investigated time course of DNA methylation following H. pylori eradication in 221 successfully H. pylori eradicated subjects with endoscopic follow‐up at leas...

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Bibliographic Details
Published in:International journal of cancer 2013-11, Vol.133 (9), p.2034-2042
Main Authors: Shin, Cheol Min, Kim, Nayoung, Lee, Hye Seung, Park, Ji Hyun, Ahn, Soyeon, Kang, Gyeong Hoon, Kim, Jung Mogg, Kim, Joo Sung, Lee, Dong Ho, Jung, Hyun Chae
Format: Article
Language:English
Subjects:
Adenomatous Polyposis Coli Protein - genetics
Biological and medical sciences
Biomarkers, Tumor - genetics
Cancer
Cancer therapies
Case-Control Studies
Deoxyribonucleic acid
DNA
DNA - analysis
DNA - genetics
DNA Methylation
Epigenetics
Female
Follow-Up Studies
Gastric cancer
Gastric Mucosa - metabolism
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis - etiology
Gastritis - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Helicobacter Infections - complications
Helicobacter Infections - genetics
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Humans
Infections
inflammation
Intestines - microbiology
Intestines - pathology
Male
Medical research
Medical sciences
Metaplasia - etiology
Metaplasia - pathology
methylation
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Grading
Polymerase Chain Reaction
Precancerous Conditions - etiology
Precancerous Conditions - pathology
Prognosis
Proto-Oncogene Proteins c-mos - genetics
Scavenger Receptors, Class E - genetics
Stomach Neoplasms - etiology
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Ulcers
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Summary:Changes of DNA methylation in gastric mucosae after eradication of Helicobacter pylori have not been clarified yet. From this background, we investigated time course of DNA methylation following H. pylori eradication in 221 successfully H. pylori eradicated subjects with endoscopic follow‐up at least for 6 months, including 114 controls, 53 subjects with gastric dysplasia and 54 patients with early gastric cancer. All dysplasia and gastric cancer patients underwent endoscopic resection at the time of enrollment. The methylation levels in LOX, APC and MOS genes from noncancerous gastric mucosae using quantitative methylation‐specific PCR, as well as the histologic findings of gastric mucosae, were compared before and after eradication. Average follow‐up duration was 26.0 months (range: 6 to 76 months). H. pylori eradication decreased methylation levels in LOX (p‐value for slope 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.28219