Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to t...

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Bibliographic Details
Published in:Organic letters 2013-09, Vol.15 (18), p.4766-4769
Main Authors: Li, Dong Bo, Rogers-Evans, Mark, Carreira, Erick M
Format: Article
Language:English
Subjects:
Animals
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Drug Discovery
Molecular Structure
Octanes - chemical synthesis
Octanes - chemistry
Oxytocin - analogs & derivatives
Spiro Compounds - chemical synthesis
Spiro Compounds - chemistry
Stereoisomerism
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Summary:New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol402127b