A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade

We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) with hepatitis B virus (HBV) carrier status who was successfully treated with tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. We administered etanercept because of the occurrenc...

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Bibliographic Details
Published in:Modern rheumatology 2013-09, Vol.23 (5), p.1029-1033
Main Authors: Zoshima, Takeshi, Matsumura, Masami, Suzuki, Yasunori, Kakuchi, Yasushi, Mizushima, Ichiro, Fujii, Hiroshi, Yamada, Kazunori, Yamagishi, Masakazu, Kawano, Mitsuhiro
Format: Article
Language:English
Subjects:
Case Report
Medicine
Medicine & Public Health
Orthopedics
Rheumatology
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Summary:We describe a patient with refractory cutaneous polyarteritis nodosa (CPAN) with hepatitis B virus (HBV) carrier status who was successfully treated with tumor necrosis factor alpha (TNF-α) blockade, using etanercept, and we review 5 similar cases. We administered etanercept because of the occurrence of repeated flares despite aggressive therapy. C-reactive protein normalization; prednisolone dose-sparing; and absence of any adverse events, including HBV reactivation with nucleotide analogue administration, or renal dysfunction, have been achieved for 8 months. TNF-α blockade should be considered for intractable CPAN.
ISSN:1439-7595
1439-7609
DOI:10.1007/s10165-012-0732-8