Evaluation of Patients with Intracranial Tumors and Central Diabetes Insipidus

The aim of the study is to evaluate the etiologic and clinical characteristics, treatment regimens, and outcome of the patients with intracranial tumors presenting with central diabetes insipidus (DI). Sixty-nine patients with intracranial tumors presenting with central DI between 1972 and 2012 were...

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Bibliographic Details
Published in:Pediatric hematology and oncology 2013-10, Vol.30 (7), p.668-673
Main Authors: Varan, Ali, Atas, Erman, Ayd n, Burça, Yalç n, Bilgehan, Akyüz, Canan, Kutluk, Tezer, Büyükpamukçu, Münevver
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain Neoplasms - complications
Brain Neoplasms - diagnosis
Brain Neoplasms - mortality
Brain Neoplasms - therapy
Child
Child, Preschool
children
diabetes insipidus
Diabetes Insipidus, Neurogenic - diagnosis
Diabetes Insipidus, Neurogenic - etiology
Diabetes Insipidus, Neurogenic - mortality
Diabetes Insipidus, Neurogenic - therapy
Disease-Free Survival
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
intracranial tumors
Male
outcome
Retrospective Studies
Survival Rate
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Summary:The aim of the study is to evaluate the etiologic and clinical characteristics, treatment regimens, and outcome of the patients with intracranial tumors presenting with central diabetes insipidus (DI). Sixty-nine patients with intracranial tumors presenting with central DI between 1972 and 2012 were retrospectively evaluated. Fifty-three out of 69 patients were included in the analysis. Male/female ratio was 1.52, median age was 7.6 years. Of 53 patients, 37 patients (69.8%) were diagnosed with Langerhans cell histiocytosis, 14 patients (26.4%) with germinoma, 1 (1.9%) with astrocytoma, and 1 (1.9%) with optic glioma. 10-year overall survival (OS) rate and disease-free survival rate for all patients were 91.7% and 52%. 10-year OS rate according to diagnostic criteria was 91% for Langerhans cell histiocytosis (LCH) cases, 79% for intracranial germinoma, which was statistically significant (P = .0001). Central DI may be very important clinical presentation of serious underlying disease in children. Intracranial tumors are the most frequent cause of DI. Most frequent diagnosis were LCH and germ cell tumors in our series.
ISSN:0888-0018
1521-0669
DOI:10.3109/08880018.2013.816984