An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant m...

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Bibliographic Details
Published in:Nature (London) 1985-11, Vol.318 (6041), p.36-40
Main Authors: Woychik, R. P, Stewart, T. A, Davis, L. G, D'Eustachio, P, Leder, P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
Cloning, Molecular
Extremities - embryology
Fundamental and applied biological sciences. Psychology
Genes, Recessive
Genetic Complementation Test
Genetics of eukaryotes. Biological and molecular evolution
Humanities and Social Sciences
Mammary Tumor Virus, Mouse - genetics
Mice - embryology
Mice - genetics
mouse mammary tumor virus
multidisciplinary
Mutation
Pedigree
Phenotype
Proto-Oncogenes
Science
Science (multidisciplinary)
Transformation, Genetic
Vertebrata
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Summary:We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant mutation that gives rise to a related limb dysmorphism. The inserted element thus provides a molecular genetic link with the control of pattern formation in the mammalian embryo.
ISSN:0028-0836
1476-4687
DOI:10.1038/318036a0