Intrinsic radiosensitivity: predictive assays that will change daily practice

The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the s...

Full description

Saved in:
Bibliographic Details
Published in:Cancer radiothérapie 2013-10, Vol.17 (5-6), p.337-343
Main Authors: Lacombe, J, Riou, O, Solassol, J, Mangé, A, Bourgier, C, Fenoglietto, P, Pèlegrin, A, Ozsahin, M, Azria, D
Format: Article
Language:fre
Subjects:
Apoptosis
Cells, Cultured - radiation effects
Fibroblasts - radiation effects
Genotype
Humans
Lymphocytes - radiation effects
Proteomics
Radiation Injuries - genetics
Radiation Tolerance - genetics
Radiation Tolerance - physiology
Radiotherapy - adverse effects
Radiotherapy Dosage
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better understand the mechanisms of radiation-induced late effects. We also present the possibilities of clinical use of predictive assays in the close future.
ISSN:1769-6658
DOI:10.1016/j.canrad.2013.07.137