Targeted Therapies in Oncology Come of Age

[...]the field has expanded exponentially, with more than 40 targeted therapies currently approved by the FDA for the treatment of malignancy.1 Among the best-studied molecular targets, epidermal growth factor receptor (EGFR) ligand binding leads to nuclear transcription via a cascade of linked phos...

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Bibliographic Details
Published in:Clinical therapeutics 2013-09, Vol.35 (9), p.1256-1257
Main Author: Klein, Andreas, MD
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Cancer
Cancer therapies
Drug Industry
Epidermal growth factor
FDA approval
Humans
Internal Medicine
Kinases
Ligands
Medical Education
Molecular Targeted Therapy - economics
Molecular Targeted Therapy - methods
Neoplasms - drug therapy
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Receptor, Epidermal Growth Factor - genetics
Reproducibility of Results
Rodents
Signal Transduction - drug effects
Signal Transduction - genetics
Tumors
United States
United States Food and Drug Administration
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Summary:[...]the field has expanded exponentially, with more than 40 targeted therapies currently approved by the FDA for the treatment of malignancy.1 Among the best-studied molecular targets, epidermal growth factor receptor (EGFR) ligand binding leads to nuclear transcription via a cascade of linked phosphorylation events amplifying through RAS/MEK/ERK and PI3K/AKT/mTOR, among others.2 EFGR is involved in mediating growth and differentiation in epithelial tissue throughout the body and drives the survival of cancers of epithelial origin, including lung and colorectal, affecting an estimated 228,000 and 143,000 new patients, respectively, in 2013 alone.3 Interestingly, the role of the EGFR pathway appears distinct in these 2 malignancies.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2013.08.006