Release of ( super(3)H)noradrenaline by alpha sub(1)-adrenoceptor agonists

Mouse isolated vas deferens preincubated with ( super(3)-H)noradrenaline was superfused and the effect of alpha sub(1)-adrenoceptor agonists was studied on the release of total radioactivity (( super(3)H)noradrenaline + super(3)H-metabolites) and ( super(3)H)noradrenaline. As determined by HPLC comb...

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Bibliographic Details
Published in:Neurochemical research 1986-01, Vol.11 (1), p.71-84
Main Authors: Vizi, E S, Somogyi, G T, Harsing, LG Jr, Zimanyi, I
Format: Article
Language:English
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Summary:Mouse isolated vas deferens preincubated with ( super(3)-H)noradrenaline was superfused and the effect of alpha sub(1)-adrenoceptor agonists was studied on the release of total radioactivity (( super(3)H)noradrenaline + super(3)H-metabolites) and ( super(3)H)noradrenaline. As determined by HPLC combined with scintillation spectrometry the release of total radioactivity in response to 1-noradrenaline is mainly due to ( super(3)H)noradrenaline. It is suggested that 1-noradrenaline, 1-phenylephrine, and ST-587 in addition to their direct effect on different receptors they also have indirect action through the release of noradrenaline which might be partly involved in the pharmacological responses. Among the alpha sub(1)-adrenoceptor agonists studied (-)-amidephrine, methoxamine and cirazoline is a better choice than 1-phenylephrine or ST-587 for selective stimulation of postjunctional alpha sub(1)-adrenoceptors, they do not release noradrenaline.
ISSN:0364-3190