C-Reactive Protein and Future Cardiovascular Events in Statin-Treated Patients with Angina Pectoris: The Extended TRUTH Study

• Published in: Journal of Atherosclerosis and Thrombosis 2013, Vol.20(9), pp.717-725
• Main Authors: Nozue, Tsuyoshi, Fukui, Kazuki, Yamamoto, Shingo, Kunishima, Tomoyuki, Umezawa, Shigeo, Onishi, Yuko, Tohyama, Shinichi, Takeyama, Youichi, Morino, Yoshihiro, Yamauchi, Takao, Hibi, Kiyoshi, Sozu, Takashi, Terashima, Mitsuyasu, Michishita, Ichiro
• Format: Article
• Language: English
• Subjects: Aged; Angina Pectoris - diagnostic imaging; Angina Pectoris - drug therapy; C-Reactive Protein - metabolism; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular event; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - drug therapy; Female; Follow-Up Studies; High-sensitivity C-reactive protein; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Ischemia - pathology; Japan; Low-density lipoprotein cholesterol; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Plaque, Atherosclerotic - diagnosis; Pravastatin - therapeutic use; Prospective Studies; Quinolines - therapeutic use; Regression Analysis; Risk Factors; Statin; Treatment Outcome; Ultrasonography, Interventional
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.18705

Aim: The TRUTH trial demonstrated that 8-month statin therapy alters the composition of coronary artery plaque using virtual histology (VH)-intravascular ultrasound (IVUS). The extended TRUTH study was conducted to evaluate the relationship between changes in coronary atherosclerosis and mid-term clinical outcomes and identify the factors associated with cardiovascular events. Methods: Of 164 patients with angina pectoris who participated in the TRUTH trial, 119 subjects with analyzable IVUS data at both enrollment and the 8-month follow-up were enrolled and observed for at least two years. The primary end point was the time to first occurrence of cardiovascular composite events, including cardiovascular death, nonfatal myocardial infarction, nonfatal cerebral infarction, unstable angina and ischemic-driven revascularization, except for target lesion revascularization. Results: The frequency of reaching the primary end point was 13% (16/119), with a mean follow-up period of 41.9±9.4 months. Although plaque regression and changes in plaque composition were not associated with future cardiovascular events, the serum high-sensitivity C-reactive protein (hs-CRP) levels at the start of the extended TRUTH study were significantly higher in the event group than in the event-free group (1.43 mg/L vs. 0.58 mg/L, p=0.01). A multivariate logistic regression analysis showed that the hs-CRP level was an independent significant predictor of cardiovascular events (odds ratio: 1.69; 95% confidence interval: 1.14-2.50, p=0.01). Conclusions: Coronary artery plaque regression and changes in plaque composition during statin therapy do not predict future cardiovascular events in patients with angina pectoris. Instead, the serum hs-CRP level can be used as a predictor of cardiovascular events.