Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis

Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-en...

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Bibliographic Details
Published in:Genetics and molecular research 2013-03, Vol.12 (3), p.3136-3145
Main Authors: Yi, C Q, Ma, C H, Xie, Z P, Cao, Y, Zhang, G Q, Zhou, X K, Liu, Z Q
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - pathology
Down-Regulation
Fibroblasts - cytology
Fibroblasts - metabolism
Gene Expression Regulation - genetics
Genome, Human
Humans
Metabolic Networks and Pathways - genetics
Oligonucleotide Array Sequence Analysis
Osteoarthritis - genetics
Osteoarthritis - pathology
Peroxisome Proliferator-Activated Receptors - genetics
Signal Transduction - genetics
Up-Regulation
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Summary:Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We found 32 highly significant pathways, including 18 downregulated and 14 upregulated pathways associated with RA. We also identified 18 highly significant pathways, including 7 downregulated and 11 up-regulated pathways associated with OA. Several such pathways were found in both RA and OA, including an upregulated PPAR signaling pathway and downregulated leukocyte transendothelial migration. Regulatory mechanisms in RA seem to be more complex than in OA. This information could be useful for diagnosis and treatment of these two diseases.
ISSN:1676-5680
1676-5680
DOI:10.4238/2013.March.11.3