Optimizing the physical form – opportunities and limitations

This review addresses the question: ‘When can optimizing the physical form rescue leads with poor drug-like properties.’ This review addresses strategies involving: (1) alternate polymorphs or solvates; (2) salts; and (3) cocrystals. Amorphous materials are also briefly addressed. Overall, it is cle...

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Bibliographic Details
Published in:Drug discovery today. Technologies 2012, Vol.9 (2), p.e73-e78
Main Authors: Byrn, Stephen R., Henck, Jan-Olav
Format: Article
Language:English
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Summary:This review addresses the question: ‘When can optimizing the physical form rescue leads with poor drug-like properties.’ This review addresses strategies involving: (1) alternate polymorphs or solvates; (2) salts; and (3) cocrystals. Amorphous materials are also briefly addressed. Overall, it is clear, based upon the unique properties that a new form can provide that optimizing the solid form can rescue a drug lead. What is not known or predictable is when an optimized form will be found or occur. Instead, one must screen to try to find a ‘home run’ form.
ISSN:1740-6749
1740-6749
DOI:10.1016/j.ddtec.2012.03.006