Circulating Adropin Concentrations in Pediatric Obstructive Sleep Apnea: Potential Relevance to Endothelial Function

Objective To test the hypothesis that concentrations of adropin, a recently discovered peptide that displays important metabolic and cardiovascular functions, are lower in obstructive sleep apnea (OSA), especially when associated with endothelial dysfunction. Study design Age-, sex-, and ethnicity-m...

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Bibliographic Details
Published in:The Journal of pediatrics 2013-10, Vol.163 (4), p.1122-1126
Main Authors: Gozal, David, MD, Kheirandish-Gozal, Leila, MD, MSc, Bhattacharjee, Rakesh, MD, Molero-Ramirez, Helena, MD, Tan, Hui-Leng, MD, Bandla, Hari P.R., MD
Format: Article
Language:English
Subjects:
Blood Proteins - analysis
Body Mass Index
Case-Control Studies
Child
Endothelium, Vascular - physiopathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hyperemia - complications
Hyperemia - diagnosis
Intercellular Signaling Peptides and Proteins
Male
Oxygen - metabolism
Pediatrics
Peptides
Polysomnography
ROC Curve
Sensitivity and Specificity
Sleep Apnea, Obstructive - blood
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Summary:Objective To test the hypothesis that concentrations of adropin, a recently discovered peptide that displays important metabolic and cardiovascular functions, are lower in obstructive sleep apnea (OSA), especially when associated with endothelial dysfunction. Study design Age-, sex-, and ethnicity-matched children (mean age, 7.2 ± 1.4 years) were included into 1 of 3 groups based on the presence of OSA in an overnight sleep study, and on the time to postocclusive maximal reperfusion (Tmax >45 seconds) with a modified hyperemic test. Plasma adropin concentrations were assayed using a commercial enzyme-linked immunosorbent assay kit. Results Among controls, the mean morning adropin concentration was 7.4 ng/mL (95% CI, 5.2-16.3 ng/mL). Children with OSA and abnormal endothelial function (EF) (OSA+ /EF+ group) had significantly lower adropin concentrations (2.7 ± 1.1 ng/mL; n = 35) compared with matched controls (7.6 ± 1.4 ng/mL; n = 35; P < .001) and children with OSA and normal EF (OSA+ /EF− group; 5.8 ± 1.5 ng/mL; n = 47; P < .001). A plasma adropin concentration .05). Conclusion Plasma adropin concentrations are reduced in pediatric OSA when endothelial dysfunction is present, and return to within normal values after adenotonsillectomy. Assessment of circulating adropin concentrations may provide a reliable indicator of vascular injury in the context of OSA in children.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.05.040