Postural Orthostatic Tachycardia Syndrome with Increased Erythrocytic Hydrogen Sulfide and Response to Midodrine Hydrochloride

Objectives To evaluate the use of erythrocytic hydrogen sulfide (H2 S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS). Study design Fifty-five children were included in this study, involving 28 children with POTS (...

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Bibliographic Details
Published in:The Journal of pediatrics 2013-10, Vol.163 (4), p.1169-1173.e2
Main Authors: Yang, Jinyan, MM, Zhao, Juan, MD, Du, Shuxu, MD, Liu, Die, MD, Fu, Chunhin, MM, Li, Xueying, MM, Chen, Stella, MM, Tang, Chaoshu, PhD, Du, Junbao, PhD, Jin, Hongfang, PhD
Format: Article
Language:English
Subjects:
Area Under Curve
Case-Control Studies
Child
Child, Preschool
children
Electrocardiography
erythrocytes
Erythrocytes - cytology
Erythrocytes - metabolism
Female
Heart Rate
Humans
hydrogen sulfide
Hydrogen Sulfide - blood
Male
Midodrine - therapeutic use
Pediatrics
Postural Orthostatic Tachycardia Syndrome - blood
Postural Orthostatic Tachycardia Syndrome - diagnosis
prediction
ROC Curve
Sensitivity and Specificity
Sympathomimetics - therapeutic use
therapeutics
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Summary:Objectives To evaluate the use of erythrocytic hydrogen sulfide (H2 S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS). Study design Fifty-five children were included in this study, involving 28 children with POTS (POTS group) and 27 healthy children (control group). Children in the POTS group received midodrine hydrochloride treatment. Erythrocytic H2 S production was measured; a receiver operating characteristic curve was used to assess if erythrocytic H2 S could predict the therapeutic response to midodrine hydrochloride treatment. Results H2 S production from erythrocytes was significantly higher in the POTS group than in the control group ( P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.04.039