Advances in pathogenesis and therapy of hemolytic uremic syndrome caused by shiga toxin‐2

Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is...

Full description

Saved in:
Bibliographic Details
Published in:IUBMB life 2013-10, Vol.65 (10), p.827-835
Main Authors: Ibarra, Cristina, Amaral, María Marta, Palermo, Marina S.
Format: Article
Language:English
Subjects:
Bacteriophage lambda - genetics
Bacteriophage lambda - pathogenicity
Diarrhea - epidemiology
Diarrhea - genetics
Diarrhea - microbiology
Diarrhea - pathology
Disease Outbreaks
Germany - epidemiology
hemolytic uremic syndrome
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - genetics
Hemolytic-Uremic Syndrome - microbiology
Hemolytic-Uremic Syndrome - pathology
Humans
O104:H4
Shiga Toxin 2 - genetics
Shiga Toxin 2 - metabolism
Shiga toxin‐2
Shiga-Toxigenic Escherichia coli - genetics
Shiga-Toxigenic Escherichia coli - pathogenicity
Virulence - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible to bloody diarrhea (hemorrhagic colitis) and the hemolytic uremic syndrome (HUS). STEC strains carry inducible lambda phages integrated into their genomes that encode Stx 1 and/or 2, with several allelic variants each one. O157:H7 is the serotype that was documented in the vast majority of HUS cases although non‐O157 serotypes have been increasingly reported to account for HUS cases. However, the outbreak that occurred in central Europe during late spring of 2011 showed that the pathogen was E. coli O104:H4. More than 4,000 persons were infected mainly in Germany, and it produced more than 900 cases of HUS resulting in 54 deaths. E. coli O104:H4 is a hybrid organism that combines some of the virulence genes of STEC and enteroaggregative E. coli specially production of Stx2 and the adherence mechanisms to intestinal epithelium. The differences in the epidemiology and presentation of E. coli pathogen meant a challenge for public health and scientific research to increase the knowledge of HUS‐pathophysiology and to improve available therapies to treat HUS. © 2013 IUBMB Life, 65(10):827‐835, 2013
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1206