Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model

ABSTRACT The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact fe...

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Published in:Journal of orthopaedic research 2013-11, Vol.31 (11), p.1757-1764
Main Authors: Chen, Hongmei, Chevrier, Anik, Hoemann, Caroline D., Sun, Jun, Picard, Genevieve, Buschmann, Michael D.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - physiology
bone marrow stimulation
cartilage repair
Cartilage, Articular - physiopathology
Cartilage, Articular - surgery
Female
Femur - pathology
Femur - physiopathology
Femur - surgery
medial femoral condyle
Menisci, Tibial - pathology
meniscus degeneration
Models, Anatomic
Models, Animal
Rabbits
trochlea
Wound Healing
X-Ray Microtomography
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Summary:ABSTRACT The influence of the location of cartilage lesions on cartilage repair outcome is incompletely understood. This study compared cartilage and bone repair in medial femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation in mature rabbits. Intact femurs from adult rabbits served as controls. Results from quantitative histomorphometry and histological scoring showed that bone marrow stimulation produced inferior soft tissue repair in MFC versus TR defects, as indicated by significantly lower % Fill (p = 0.03), a significant increase in collagen type I immunostaining (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.22422