New genetic findings in parotid gland pleomorphic adenomas

Background Despite numerous studies, the tumor biology of pleomorphic adenomas, the most common salivary gland tumors, is still not completely defined. In order to identify further candidate genes important for tumor biology of pleomorphic adenomas, extended cytogenetic and molecular analysis are ma...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2013-10, Vol.35 (10), p.1431-1438
Main Authors: Wemmert, Silke, Willnecker, Vivienne, Brunner, Christian, Wenzel, Gentiana Ioana, Sauter, Birgit, Meinelt, Heike, Bartholmé, Nadia, Saada, Carolin, Bohle, Rainer Maria, Urbschat, Steffi, Schick, Bernhard
Format: Article
Language:English
Subjects:
Adenoma, Pleomorphic - genetics
Adenoma, Pleomorphic - pathology
Adenoma, Pleomorphic - surgery
Adult
Aged
Carcinogenesis - genetics
CGH
Chromosome Aberrations
Cohort Studies
Cytogenetic Analysis - methods
Female
FISH
Gene Expression Regulation, Neoplastic
genetic alterations
Genetic Predisposition to Disease - epidemiology
Genomics
Germany
Humans
In Situ Hybridization, Fluorescence - methods
Male
Middle Aged
Parotid Neoplasms - genetics
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
pleomorphic adenoma
Preoperative Care - methods
Salivary Gland Neoplasms - genetics
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - surgery
salivary gland tumor
Sensitivity and Specificity
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Despite numerous studies, the tumor biology of pleomorphic adenomas, the most common salivary gland tumors, is still not completely defined. In order to identify further candidate genes important for tumor biology of pleomorphic adenomas, extended cytogenetic and molecular analysis are mandatory. Methods We performed a detailed molecular cytogenetic analysis using comparative genomic hybridization (CGH) followed by fluorescence in situ hybridization (FISH) with probes for chromosome X, 16p, 17, and 20 on a large cohort of pleomorphic adenomas (n = 29). Results We could confirm previously described deletions in pleomorphic adenomas affecting 16p, 17, 20q, and 22 by FISH and/or CGH analysis. Moreover, our CGH study revealed novel candidate regions on 8p23.1pter, 9p, 10q25.1q25.3, and 11q24qter in the series of analyzed pleomorphic adenomas. Conclusion Our present study reveals new insights in novel candidate regions implicated in pleomorphic adenoma tumorigenesis which should be considered in further molecular studies. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1431–1438, 2013
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23147