Diffusion Tensor Imaging Analysis for Psychiatric Disorders

The pathophysiology of psychiatric disorders is complex and cannot be easily assessed by laboratory studies. Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique increasingly used for noninvasive and quantitative evaluation of abnormalities of the cerebral white matter because it...

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Bibliographic Details
Published in:Magnetic Resonance in Medical Sciences 2013, Vol.12(3), pp.153-159
Main Authors: SHIZUKUISHI, Takashi, ABE, Osamu, AOKI, Shigeki
Format: Article
Language:English
Subjects:
Brain - pathology
cerebral white matter
diffusion tensor analysis
Diffusion Tensor Imaging - methods
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Mental Disorders - pathology
Nerve Fibers, Myelinated - pathology
neuroimaging
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Summary:The pathophysiology of psychiatric disorders is complex and cannot be easily assessed by laboratory studies. Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique increasingly used for noninvasive and quantitative evaluation of abnormalities of the cerebral white matter because it provides exquisite details on tissue microstructures and also can perform sophisticated computer-based analyses. We review basic principles of DTI; methods of diffusion tensor analysis; recent DTI findings in major psychiatric diseases, such as schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorder; and factors to keep in mind when interpreting the results of DTI analysis. We recommend the frequent use of DTI as a routine clinical protocol to assess white matter abnormalities in patients with psychiatric disorders.
ISSN:1347-3182
1880-2206
DOI:10.2463/mrms.2012-0082